乙烯-1,2-二胺 | 53120-95-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 乙烯-1,2-二胺
• 英文名称: cis-1,2-ethylenediamine
• 英文别名: (Z)-ethene-1,2-diamine
• CAS: 53120-95-9
• 化学式: C₂H₆N₂
• 分子量: 58.083
• InChiKey: MLCJWRIUYXIWNU-UPHRSURJSA-N

物化性质

• 沸点：
  115.6±23.0 °C(Predicted)
• 密度：
  0.929±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  乙烯-1,2-二胺 、 二苯基乙炔 在 碘苯二乙酸 、 氧气 、 三甲基乙酸 作用下， 以 二甲基亚砜 为溶剂， 以80%的产率得到2,3-二苯基哌嗪
  参考文献：
  名称：

  Efficient synthesis of quinoxalines with hypervalent iodine as a catalyst

  摘要：

  Various biologically important quinoxalines were efficiently synthesized in excellent yields via one-pot reaction between 1,2-diaminobenzenes and internal alkynes. The method utilizes inexpensive and readily available hypervalent iodine source, such as (diacetoxyiodo)benzene (PhI(OAc)(2)) and proved to be a better alternative as compared to expensive transition metal catalysts. Quinoxaline 4i [(2-phenyl-3-(3,4,5-trimethoxy phenyl)quinoxaline)] was evaluated for leukemia cancer cell lines and turned out to be a good candidate. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.09.027

文献信息

• Efficient synthesis of quinoxalines with hypervalent iodine as a catalyst
  作者：Chung-Yu Chen、Wan-Ping Hu、Mei-Chun Liu、Pi-Cheng Yan、Jeh-Jeng Wang、Mei-Ing Chung

  DOI：10.1016/j.tet.2013.09.027

  日期：2013.11

  Various biologically important quinoxalines were efficiently synthesized in excellent yields via one-pot reaction between 1,2-diaminobenzenes and internal alkynes. The method utilizes inexpensive and readily available hypervalent iodine source, such as (diacetoxyiodo)benzene (PhI(OAc)(2)) and proved to be a better alternative as compared to expensive transition metal catalysts. Quinoxaline 4i [(2-phenyl-3-(3,4,5-trimethoxy phenyl)quinoxaline)] was evaluated for leukemia cancer cell lines and turned out to be a good candidate. (C) 2013 Elsevier Ltd. All rights reserved.