N-(1-adamantyl)-N'-propylsulfamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: N-(1-adamantyl)-N'-propylsulfamide
• 英文别名: N-adamant-1-yl-N'-propylsulfamide；N-(propylsulfamoyl)adamantan-1-amine
• 化学式: C₁₃H₂₄N₂O₂S
• 分子量: 272.412
• InChiKey: LLVZKPBHOPZCRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙基氨磺酰氯化物 、 金刚烷胺 在 TEA 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以74%的产率得到N-(1-adamantyl)-N'-propylsulfamide
  参考文献：
  名称：

  Novel Sulfamide Analogs of Oleoylethanolamide Showing In Vivo Satiety Inducing Actions and PPARα Activation

  摘要：

  Long chain saturated and unsaturated alkyl sulfamide and propyl sulfamide derivatives, analogs of oleoylethanolamide, have been synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPAR alpha) activators. Additionally, the anorexic effects of the new compounds have been studied in vivo in food-deprived rats. Among the active compounds N-octadecyl-N'-propylsulfamide (7) has been identified as a potent hypolipidemic compound, a potent feeding suppressant, and a concentration-dependent activator of PPAR alpha.

  DOI：

  10.1021/jm0601102

文献信息

• Acyclic Sulfamide Derivatives
  申请人：Rodriguez De Fonseca Fernando Antonio

  公开号：US20090221710A1

  公开（公告）日：2009-09-03

  The present invention is related to acyclic sulfamide derivatives, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulfamide derivatives are also useful for cosmetic use.

  本发明涉及无环磺酰胺衍生物，用于制造诱导饱腹感和控制摄入量、调节体内脂肪和脂质代谢的药物，以及用于制造治疗或预防糖尿病和心血管疾病的药物。无环磺酰胺衍生物还可用于化妆品。
• ACYCLIC SULFAMIDE DERIVATIVES
  申请人：Fundacion Imabis. Inst. Meditteraneo para el Avan e de la Biotecnologia y la Investigacion Sanitaria

  公开号：EP1984326B1

  公开（公告）日：2017-05-03
• US8188312B2
  申请人：——

  公开号：US8188312B2

  公开（公告）日：2012-05-29
• Novel Sulfamide Analogs of Oleoylethanolamide Showing In Vivo Satiety Inducing Actions and PPARα Activation
  作者：Carolina Cano、Javier Pavón、Antonia Serrano、Pilar Goya、Juan Antonio Paez、Fernando Rodriguez de Fonseca、Manuel Macias-Gonzalez

  DOI：10.1021/jm0601102

  日期：2007.1.1

  Long chain saturated and unsaturated alkyl sulfamide and propyl sulfamide derivatives, analogs of oleoylethanolamide, have been synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPAR alpha) activators. Additionally, the anorexic effects of the new compounds have been studied in vivo in food-deprived rats. Among the active compounds N-octadecyl-N'-propylsulfamide (7) has been identified as a potent hypolipidemic compound, a potent feeding suppressant, and a concentration-dependent activator of PPAR alpha.