Cu(2,2'-bipyridyl)Cl2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Cu(2,2'-bipyridyl)Cl2
• 英文别名: CuCl2(2,2'-bipyridine)；Cu(2,2'-bipyridine)Cl2；Copper;2-pyridin-2-ylpyridine;chloride
• 化学式: C₁₀H₈N₂*2Cl*Cu
• 分子量: 290.639
• InChiKey: JVOSHAXJVHCHBA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.85
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Cu(2,2'-bipyridyl)Cl2 在 2,2'-联吡啶 作用下， 以 solid 为溶剂， 生成
  参考文献：
  名称：

  Stepwise reaction of CuCl2 · 2H2O with 2,2′-bipyridyl in the solid state

  摘要：

  A consecutive reaction between two solids, CuCl2 . 2H(2)O and 2,2'-bipyridyl, in a 1:2 molar ratio proceeds in two steps: CuCl2 . 2H(2)O first converts to Cu(bipy)Cl-2, then Cu(bipy)Cl-2 turns into Cu(bipy)(2)Cl-2 . 2H(2)O. This is because the second step of the reaction is much slower than the first. The heat of the two reactions has been measured. (C) 1995 Academic Press, Inc.

  DOI：

  10.1016/0022-4596(95)80044-p
• 作为产物：
  描述：

  catena-dichloro(3,6-dithiaoctane)copper(II) 在 2,2'-bipyridine 作用下， 以 not given 为溶剂， 生成 Cu(2,2'-bipyridyl)Cl2
  参考文献：
  名称：

  硫配体金属配合物。第6部分。2,5-二硫代己烷和3,6-二硫代辛烷的铜配合物

  摘要：

  二硫醚2,4-二硫代己烷（dth）和3,6-二硫代辛烷（dto）与Cu II和Cu I形成以下配合物，其中一些已被报道：Cu（BF 4）2 L 2和CuX 2 L（L = dth或dto，X = Cl或Br）；[CuL 2 ] X（L ＝ dth或dto。X＝ SF，：L ＝ dth，X ＝ ClO 4）；CuXL（L = dth，X = Cl，Br或I； L = dto，X = I或SCN）；和（CuCl）2L（L = dto，X = Cl或Br）。复合物已通过多种物理化学技术进行了表征，并在可能的地方提出了结构。讨论了铜-硫键的性质，并得出结论，硫醚不会与Cu II形成明显的π键。螯合的硫醚配体容易被取代，例如从CuCl 2 L（L = dth或dto）和CuCl（dth）取代。通过各种配体（例如吡啶，吡咯烷，2,2'-联吡啶基，乙二胺，PPh 3，PMe 3 S和Na [S 2 PMe

  DOI：

  10.1039/dt9760002375

文献信息

• Spectrophotometric determination of formation constants of copper(II) complexes with 2,2′-bipyridyl, 1,10-phenanthroline and their halides in methanol
  作者：José J.N. Segoviano-Garfias、Mónica Nájera-Lara、María de la Luz Pérez-Arredondo、Varinia López-Ramírez、C.A. Rubio-Jimenez、Juan Antonio Ramírez-Vázquez、Rafael Moreno-Esparza

  DOI：10.1016/j.molstruc.2017.06.112

  日期：2017.11

  high costs. Copper complexes that mimic blue copper proteins could represent an alternative as electronic transfer agent with lower costs. In this work, we conducted a spectrophotometric study of the speciation of copper(II) complexes with 2,2′-bipyridyl, 1,10-phenanthroline and their ternary complexes with chloride and bromide, at 303 K. For the copper–2,2′-bipyridyl complexes, the formation constants

  摘要 染料敏化太阳能电池中使用的氧化还原介质存在几个缺点：尽管成本高昂，但几个研究小组已经推测出可能使用蓝铜蛋白作为电子介体。模拟蓝色铜蛋白的铜配合物可以作为一种成本较低的电子转移剂替代。在这项工作中，我们在 303 K 下对铜 (II) 与 2,2'-联吡啶、1,10-菲咯啉的配合物及其与氯化物和溴化物的三元配合物的形态形成进行了分光光度研究。对于铜-2， 2'-联吡啶配合物，得到的形成常数为：log β 110 = 7.57 ± 0.08，log β 120 = 13.26 ± 0.11 和 log β 130 = 17.21 ± 0.14。对于铜-2,2'-联吡啶与氯化物或溴化物的三元体系，分别为：log β 111 = 12.06 ± 0.06 和 log β 111 = 11.23 ± 0.01。此外，铜-1,10-菲咯啉配合物的形成常数为 log β 110 = 4.21 ± 0
• Synthesis, Structural, Magnetic and Thermal Characterization of {[Cu(bipy)] ₂ (μ‐HP ₂ O ₇ )(μ‐Cl)}·H ₂ O
  作者：Oluwatayo F. Ikotun、Elizabeth M. Higbee、Wayne Ouellette、Francesc Lloret、Miguel Julve、Robert P. Doyle

  DOI：10.1002/ejic.200800617

  日期：2008.11

  hydrogen bonding between the lattice water molecule and the bridging chloro atom create a 1D network. Variable-temperature magnetic susceptibility measurements show the occurrence of a weak antiferromagnetic interaction with a maximum at 3.0 K. The analysis of the magnetic data in the whole temperature range (1.9–300 K) allows the determination of the value of the intramolecular magnetic coupling (J =

  氢氧化铜 (II) 与 2,2'-联吡啶 (bipy) 和焦磷酸钠在环境条件下在 pH 1.6 的水中以 2:2:1 的化学计量比反应。由此产生的中性双核 CuII 复合物具有一个桥接组，其中包含桥接单质子化焦磷酸盐和一个单原子氯桥（使其成为第一个焦磷酸盐桥接的配位络合物，在金属中心之间包含一个替代的、额外的卤化物桥）。单晶 X 射线衍射研究表明复合物为 [Cu(bipy)]2(μ-HP2O7)(μ-Cl)}·H2O。该结构由二聚体铜 (II) 系统组成，每个金属离子均呈方形金字塔几何形状。不对称的 [Cu(bipy)]2+ 单元由双二齿焦磷酸盐和轴向桥接的氯原子桥接。结构中加入额外的桥（卤化物）和质子化焦磷酸盐（HP2O73-）的存在对于该结构家族来说都是罕见的。来自相邻双核配合物的双配体之间的分子间 π-π 相互作用以及晶格水分子和桥接氯原子之间的氢键形成一维网络。变温磁化率测量显示发生了弱反铁磁相互作用，最大值为
• Insertion reaction of carbon disulfide into copper-carbon bonds of aromatic organocopper(I) compounds, in the presence of 2,2′-bipyridine and 1,10-phenanthroline. X-ray diffraction structures of the [(CuS3C-o-tolyl)phen], [(CuS3C-o-tolyl)2phen] and [Cu2(S3C-o-tolyl)(S2C-o-tolyl)bipy] complexes
  作者：A. Camus、N. Marsich、A.M. Manotti Lanfredi、F. Ugozzoli

  DOI：10.1016/s0020-1693(00)84827-6

  日期：1990.9

  presence of nitrogen chelating ligands (LL=2,2′-bipyridine, 1,10-phenanthroline) the insertion reaction of CS2 into the copper-carbon bond of arylcopper(I) compounds (ArPh, o- and p-tolyl) gave adducts of Cu(I) dithiocarboxylates with LL, whose stoicheiometry depended upon the ligand and the aryl moiety. Co-formation of perthio and perthiodithio derivatives was suggested by hydrolysis of the rough products

  摘要在氮螯合配体（LL = 2,2'-联吡啶，1,10-菲咯啉）存在下，CS2插入芳基铜（I）化合物（ArPh，o-和p）的铜-碳键中的插入反应-甲苯基）生成二硫代羧酸铜（I）与LL的加合物，其化学计量取决于配体和芳基部分。通过粗产物的水解表明过硫代和过硫代二硫代衍生物的共形成。通过与真实样品进行比较，通过其他途径制备并通过IR光谱对加合物进行鉴定。通过[[CuS3C-oT）phen]（I），[（CuS3C-oT）2phen]（II）和[Cu2（S3C-oT）（S2C-oT）bipy]的X射线衍射分析确定了晶体结构。 （三）配合物。晶体数据：C20H15CuN2S3（I），空间群P 1，a = 14.135（3），b = 7.659（3），c = 9.115（3）A，α= 73.33（2），β= 96.89（3），γ = 96。73（3）°，Z = 2；C28H22Cu2N2S6（II），空间组P
• Antibacterial activity and pharmacological effect of some mixed-ligand tris-chelates of copper(II) containing neutral N,N-donors and kinetics study of the novel synthetic route for the complexes
  作者：P. Majumdar、B. Banerjee、D. Ghosh

  DOI：10.4314/bcse.v33i3.8

  日期：——

  positive and gram negative bacteria and hence bacteriostatic agents. These copper(II) complexes were synthesized easily at room temperature by the novel silver(I) assisted trans -metallation reaction and kinetic study of the reactions suggest pseudo zero order. KEY WORDS : Copper(II)tris-chelates, Neutral N,N-donors, Bacteriostatic agent, Silver(I) assisted reaction, Kinetics study Bull. Chem. Soc. Ethiop

  摘要 。本工作描述了六种含N-对甲苯基吡啶-2-醛亚胺的铜（II）的混合配体三螯合物的体外抗菌活性和药理作用。1,10-菲咯啉和2,2'-联吡啶为中性N，N-供体，对水性培养基中某些革兰氏阳性和革兰氏阴性细菌菌株。六个复合物都具有令人鼓舞的潜力，可以抑制某些革兰氏阳性和革兰氏阴性细菌的生长，从而抑制抑菌剂的生长。这些铜（II）配合物可在室温下通过新型银（I）辅助的反金属化反应轻松合成，反应的动力学研究表明伪零级。关键词：三（II）铜螯合物，中性N，N供体，抑菌剂，银（I）辅助反应，动力学研究。化学 Soc。埃塞俄比亚。2019，33（3），475-484。
• Copper(II)–fluoroquinolone complexes with anti-Trypanosoma cruzi activity and DNA binding ability
  作者：Darliane A. Martins、Ligiane R. Gouvea、Denise da Gama Jean Batista、Patrícia Bernardino da Silva、Sonia R. W. Louro、Maria de Nazaré C. Soeiro、Letícia R. Teixeira

  DOI：10.1007/s10534-012-9565-3

  日期：2012.10

  Copper(II) complexes of fluoroquinolone antibacterial agents levofloxacin (LEV) and sparfloxacin (SPAR), containing or not a nitrogen donor heterocyclic ligand, 2,2'-bipyridine (bipy) or 1,10-phenathroline (phen), were prepared and characterized. The complexes are of the type [CuCl2(H2O)(L)], [CuCl(bipy)(L)]Cl and [CuCl2(phen)(L)], where L = LEV or SPAR. The data suggest that LEV and SPAR act as zwitterionic bidentade ligands coordinated to Cu(II) through the carboxylate and ketone oxygen atoms. The electron paramagnetic resonance spectra of the [CuCl(bipy)(L)]Cl and [CuCl2(phen)(L)] complexes (L = LEV and SPAR) in aqueous and DMSO solutions indicate mixture of mononuclear and binuclear forms. The Cu(II) complexes, together with the corresponding ligands, were evaluated for their trypanocidal activity in vitro against Trypanosoma cruzi, the causative agent of Chagas disease. The assays performed against bloodstream trypomastigotes showed that all complexes were more active than their corresponding ligands. Complexes [CuCl2(phen)(LEV)] and [CuCl2(phen)(SPAR)] were revealed, among all studied compounds, to be the most active with IC50 = 1.6 and 4.7 mu M, respectively, both presenting a superior effect than benznidazole. The interactions of fluoroquinolones and their Cu(II) complexes with calf-thymus DNA were investigated. These compounds showed binding properties towards DNA, with moderated binding constants values, suggesting that this structure may represent a parasite target.