3-hydroxy-1,1-dimethyl pyrrolidinium bromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-hydroxy-1,1-dimethyl pyrrolidinium bromide
• 英文别名: quarternary amino alcohol；1,1-Dimethyl-3-hydroxypyrrolidinium Bromide；1,1-dimethylpyrrolidin-1-ium-3-ol;bromide
• 化学式: Br*C₆H₁₄NO
• 分子量: 196.087
• InChiKey: MXGQTBBUTOWGNR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.17
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甘罗溴铵 在 sodium hydroxide 作用下， 以 水 为溶剂， 以92%的产率得到2-环戊基-2-羟基苯乙酸
  参考文献：
  名称：

  [EN] GLYCOPYRRONIUM FATTY ACID SALTS AND METHODS OF MAKING SAME
  [FR] SELS D'ACIDES GRAS DE GLYCOPYRRONIUM ET LEURS PROCÉDÉS DE PRODUCTION

  摘要：

  已经开发出新型的格隆溴铵脂肪酸盐。采用双相反应条件，使格隆溴铵与碱金属和碱土金属的脂肪酸盐发生所需的离子交换反应，以形成格隆溴铵脂肪酸盐。在优选实施例中，反应混合物中过量的游离脂肪酸稳定了格隆溴铵脂肪酸盐，减少了杂质酸A的形成。在某些优选实施例中，反应混合物中添加0.2到1.2摩尔当量的过量游离脂肪酸。在另一实施例中，反应混合物中添加了大约1.2摩尔当量的过量游离脂肪酸。

  公开号：

  WO2016204998A1

文献信息

• Glycopyrronium fatty acid salts and methods of making same
  申请人：QAAM PHARMACEUTICALS, LLC

  公开号：US10519109B2

  公开（公告）日：2019-12-31

  Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.

  新型甘草酸铵脂肪酸盐已经研制成功。双相反应条件使溴化甘草酸铵与碱金属和碱土金属的脂肪酸盐之间发生所需的反离子交换反应，从而形成甘草酸铵脂肪酸盐。在优选的实施方案中，反应混合物中过量的游离脂肪酸可以稳定甘草酸铵脂肪酸盐，减少杂质酸 A 的形成。在另一个实施方案中，向反应混合物中加入约 1.2 摩尔当量的过量游离脂肪酸。
• Glycopyrronium Fatty Acid Salts and Methods of Making Same
  申请人：QAAM PHARMACEUTICALS, LLC

  公开号：US20180179156A1

  公开（公告）日：2018-06-28

  Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.
• [EN] GLYCOPYRRONIUM FATTY ACID SALTS AND METHODS OF MAKING SAME<br/>[FR] SELS D'ACIDES GRAS DE GLYCOPYRRONIUM ET LEURS PROCÉDÉS DE PRODUCTION
  申请人：QAAM PHARMACEUTICALS LLC

  公开号：WO2016204998A1

  公开（公告）日：2016-12-22

  Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.

  已经开发出新型的格隆溴铵脂肪酸盐。采用双相反应条件，使格隆溴铵与碱金属和碱土金属的脂肪酸盐发生所需的离子交换反应，以形成格隆溴铵脂肪酸盐。在优选实施例中，反应混合物中过量的游离脂肪酸稳定了格隆溴铵脂肪酸盐，减少了杂质酸A的形成。在某些优选实施例中，反应混合物中添加0.2到1.2摩尔当量的过量游离脂肪酸。在另一实施例中，反应混合物中添加了大约1.2摩尔当量的过量游离脂肪酸。