2,5-bis(4-hydroxyphenyl)furan

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2,5-bis(4-hydroxyphenyl)furan
• 英文别名: 2,5-Bis(4-Hydroxyphenyl)Furan；4-[5-(4-hydroxyphenyl)furan-2-yl]phenol
• 化学式: C₁₆H₁₂O₃
• 分子量: 252.269
• InChiKey: RCFFEJVLKMIHIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,5-Bis(4-methoxyphenyl)furan 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以65%的产率得到2,5-bis(4-hydroxyphenyl)furan
  参考文献：
  名称：

  Thiophene-Core Estrogen Receptor Ligands Having Superagonist Activity

  摘要：

  To probe the importance of the heterocyclic core of estrogen receptor (ER) ligands, we prepared a series of thiophene-core ligands by Suzuki cross coupling of aryl boronic acids with bromo-thiophenes and we assessed their receptor binding and cell biological activities. The disposition of the phenol substituents on the thiophene core, at alternate or adjacent sites, and the nature of substituents on these phenols, all contribute to binding affinity and subtype selective. Most of the bis(hydroxyphenyl)-thiophenes were ER beta selective, whereas the tris(hydroxyphenyl)-thiophenese were ER alpha selective; analogous furan-core compounds generally have lower affinity and less selectivity. Some diarylthiophenes show distinct superagonist activity, in reporter gene assays, giving maximal activities 2-3 times that of estradiol, and modeling suggests that these ligands have a different interaction with a hydrogen-bonding residue in helix-11 Ligand-core modification may be a new strategy for developing ER ligands whose selectivity is based on having transcriptional activity greater than that of estradiol.

  DOI：

  10.1021/jm400157e

文献信息

• A porphyrin porous organic polymer with bicatalytic sites for highly efficient one-pot tandem catalysis
  作者：Rui Shen、Wei Zhu、Xiaodong Yan、Tao Li、Yong Liu、Yunxing Li、Siyuan Dai、Zhi-Guo Gu

  DOI：10.1039/c8cc08918c

  日期：——

  A novel porphyrin-based porous organic polymer PPOP-1(Pd) with bifunctional catalytic sites was constructed via imine condensation of tetra(4-aminophenyl)porphyrin and acenaphthenequinone. PPOP-1(Pd) containing Pd(II)-porphyrin and Pd(II)-α-diimine moieties exhibits excellent catalytic activity and outstanding reusability for tandem catalytic reactions of C–H arylation and Suzuki coupling.

  通过四（4-氨基苯基）卟啉与啶亚胺的亚胺缩合，构建了具有双功能催化位点的新型卟啉基多孔有机聚合物PPOP-1（Pd）。含有Pd（II）-卟啉和Pd（II）-α-二亚胺部分的PPOP -1（Pd）具有出色的催化活性和出色的可重复使用的C-H芳基化和Suzuki偶联反应。
• Kao et al., Proceedings - Indian Academy of Sciences, Section A, 1950, # 32, p. 162,166
  作者：Kao et al.

  DOI：——

  日期：——
• POLYMERIZABLE COMPOUND HAVING OXYGEN-CONTAINING FIVE-MEMBERED RING, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC CORPORATION

  公开号：US20150034871A1

  公开（公告）日：2015-02-05

  An object is to provide a polymerizable compound having high polymerization reactivity, a high conversion ratio and high solubility in a liquid crystal composition, a polymerizable composition containing the compound, a liquid crystal composite prepared from the composition, and a liquid crystal display device having the composite. A solution is a polymerizable compound represented by formula (1). In the formula, for example, P 1 and P 2 are —OCO—(CH 3 )C═CH 2 ; S 1 and S 2 are a single bond; ring A 1 , ring A 2 and ring A 3 are 1,4-phenylene; Z 1 , Z 2 and Z 3 are a single bond; two of G is —CH═ or —N═; and a is 0 or 1.
• US9315603B2
  申请人：——

  公开号：US9315603B2

  公开（公告）日：2016-04-19
• Thiophene-Core Estrogen Receptor Ligands Having Superagonist Activity
  作者：Jian Min、Pengcheng Wang、Sathish Srinivasan、Jerome C. Nwachukwu、Pu Guo、Minjian Huang、Kathryn E. Carlson、John A. Katzenellenbogen、Kendall W. Nettles、Hai-Bing Zhou

  DOI：10.1021/jm400157e

  日期：2013.4.25

  To probe the importance of the heterocyclic core of estrogen receptor (ER) ligands, we prepared a series of thiophene-core ligands by Suzuki cross coupling of aryl boronic acids with bromo-thiophenes and we assessed their receptor binding and cell biological activities. The disposition of the phenol substituents on the thiophene core, at alternate or adjacent sites, and the nature of substituents on these phenols, all contribute to binding affinity and subtype selective. Most of the bis(hydroxyphenyl)-thiophenes were ER beta selective, whereas the tris(hydroxyphenyl)-thiophenese were ER alpha selective; analogous furan-core compounds generally have lower affinity and less selectivity. Some diarylthiophenes show distinct superagonist activity, in reporter gene assays, giving maximal activities 2-3 times that of estradiol, and modeling suggests that these ligands have a different interaction with a hydrogen-bonding residue in helix-11 Ligand-core modification may be a new strategy for developing ER ligands whose selectivity is based on having transcriptional activity greater than that of estradiol.