2-chloro-4,6-bis(1-methylethoxy)-1,3,5-triazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2-chloro-4,6-bis(1-methylethoxy)-1,3,5-triazine
• 英文别名: 2-chloro-4,6-diisopropoxy-1,3,5-triazine；2-Chloro-4,6-bis(propan-2-yloxy)-1,3,5-triazine；2-chloro-4,6-di(propan-2-yloxy)-1,3,5-triazine
• 化学式: C₉H₁₄ClN₃O₂
• 分子量: 231.682
• InChiKey: UIMHAKPOIRGDEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-chloro-4,6-bis(1-methylethoxy)-1,3,5-triazine 、 三(2-氨基乙基)胺 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以60%的产率得到N¹-(4,6-diisopropoxy-1,3,5-triazin-2-yl)-N²,N²-bis[2-[(4,6-diisopropoxy-1,3,5-triazin-2-yl)amino]ethyl]ethane-1,2-diamine
  参考文献：
  名称：

  Preparation of Some Novel Trisubstituted 1,3,5-Triazines and Hybrid Linker Mode 1,3,5-Triazine Derivatives and Their Biological Evaluation

  摘要：

  We report a new route to the preparation of C-3-symmetrical multivalent hybrid-type molecules having a tris-aminoethylamine (TAEA) linker group and 1,3,5-triazine recognition moieties in the molecule and we also report the results of biological evaluation of their anti-herpes simplex virus type 1 (anti-HSV-1) activity and cytotoxic activity against Vero cells. Among the tested compounds, a new mid-size C-2-symmetrical multivalent hybrid-type molecule (10aq) showed a high level of anti-HSV-1 activity (EC50 = 19.7 mu M) with low cytotoxicity (CC50 > 200 mu M) against Vero cells. A new C-S-symmetrical multivalent derivative (4ab) also showed high anti-HSV-1 activity (EC50 = 1.77 mu M) with low cytotoxicity (CC50 > 200 mu M). The hybrid-type C-2-symmetrical multivalent mid-size molecule (10aq) seems to be an interesting new lead in the search for new hybrid-type symmetrical multivalent antiviral compounds.

  DOI：

  10.3987/com-19-14052
• 作为产物：
  描述：

  三聚氯氰 、 异丙醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 12.5h， 以61%的产率得到2-chloro-4,6-bis(1-methylethoxy)-1,3,5-triazine
  参考文献：
  名称：

  JP5963140

  摘要：

  公开号：
• 作为试剂：
  描述：

  2-苯乙胺 、 Cbz-DL-苯丙氨酸 在 2-chloro-4,6-bis(1-methylethoxy)-1,3,5-triazine 、 (R)-4,5-dihydro-4-methyl-2,6-diphenyl-3H-dinaphtho[2,1-c:1',2'-e]azepine 、 异丙醇 作用下， 以 正己烷 为溶剂， 反应 1.5h， 以32%的产率得到Cbz-L-Phe-NHCH₂CH₂Ph
  参考文献：
  名称：

  JP5963140

  摘要：

  公开号：

文献信息

• Method for preserving quaternary ammonium salt
  申请人：——

  公开号：US20030153785A1

  公开（公告）日：2003-08-14

  A method of improving the stability of a quaternary ammonium salt and a method of efficiently preparing the quaternary ammonium salt having improved stability.

  一种提高季铵盐稳定性的方法和一种高效制备稳定性提高的季铵盐的方法。
• PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE AND CONDENSING AGENT COMPRISING QUATERNARY AMMONIUM SALT
  申请人：TOKUYAMA CORPORATION

  公开号：EP1085000A1

  公开（公告）日：2001-03-21

  A process for producing a carboxylic acid derivative characterized by mixing a quaternary ammonium salt having a specific triazine ring in the molecule, a carboxylic acid compound, and a compound having a nucleophilic functional group to conduct the condensation reaction of the carboxylic acid compound with the compound having a nucleophilic functional group; and a condensing agent comprising the quaternary ammonium salt. By the process, the condensation reaction can be conducted under mild conditions and a carboxylic acid derivative, especially an amide or ester compound, can be obtained in high yield.

  一种生产羧酸衍生物的工艺，其特征在于将分子中含有特定三嗪环的季铵盐、羧酸化合物和具有亲核官能团的化合物混合，以进行羧酸化合物与具有亲核官能团的化合物的缩合反应；以及由季铵盐组成的缩合剂。通过该工艺，可在温和条件下进行缩合反应，并以高产率获得羧酸衍生物，特别是酰胺或酯类化合物。
• METHOD FOR MANUFACTURING POLYROTAXANE
  申请人：Sumitomo Seika Chemicals Co., Ltd.

  公开号：EP2899221A1

  公开（公告）日：2015-07-29

  The present invention aims to provide a method for producing a polyrotaxane which enables industrially advantageous production of a polyrotaxane with a high inclusion rate. The present invention relates to a method for producing a polyrotaxane that includes a cyclodextrin; a compound having a repeating structural unit represented by the following formula (1), and threading through a cavity of the cyclodextrin in a skewered manner to be included in the cyclodextrin; and capping groups individually placed at each end of a molecule of the compound having a repeating structural unit represented by the formula (1) to prevent the cyclodextrin from separating, the method comprising: a step 1 of mixing the compound having a repeating structural unit represented by the formula (1) and the cyclodextrin in an aqueous medium to prepare an aqueous dispersion of pseudopolyrotaxan particles in which the compound having a repeating structural unit represented by the formula (1) is included in a cavity of a cyclodextrin molecule in a skewered manner; and a step 2 of mixing a triazine compound represented by the formula (2), a compound having at least one tertiary amino group, the aqueous dispersion of pseudopolyrotaxane particles prepared in the step 1, and a capping agent to introduce capping groups individually at each end of a molecule of the compound having a repeating structural unit represented by the formula (1) in the pseudopolyrotaxane particles, wherein, in the formula (2), R1 and R2 are each independently a C1-C4 alkyl group or a C6-C8 aryl group, and X represents a halogen atom.

  本发明旨在提供一种生产聚游离基聚氧乙烯醚的方法，该方法能够以工业优势生产出具有高包合率的聚游离基聚氧乙烯醚。 本发明涉及一种生产聚龙沙烷的方法，该方法包括环糊精；具有下式（1）所代表的重复结构单元的化合物，并以串联的方式穿过环糊精的空腔以包含在环糊精中；以及单独置于具有下式（1）所代表的重复结构单元的化合物分子两端的封端基团，以防止环糊精分离，该方法包括：步骤 1 在水性介质中混合具有式（1）所代表的重复结构单元的化合物和环糊精，以制备假多聚糖颗粒的水性分散液，其中具有式（1）所代表的重复结构单元的化合物以串联方式包含在环糊精分子的空腔中；步骤 2：将式（2）代表的三嗪化合物、具有至少一个叔氨基的化合物、步骤 1 中制备的假多聚氧乙烯醚颗粒水分散液和封端剂混合，以便在假多聚氧乙烯醚颗粒中具有式（1）代表的重复结构单元的化合物分子的两端分别引入封端基团、 其中，在式 (2) 中，R1 和 R2 各自独立地为 C1-C4 烷基或 C6-C8 芳基，X 代表卤原子。
• Method for storing quaternary ammonium salt
  申请人：——

  公开号：US20040147740A1

  公开（公告）日：2004-07-29

  A method of improving the stability of a quaternary ammonium salt and a method of efficiently preparing the quaternary ammonium salt having improved stability.

  一种提高季铵盐稳定性的方法和一种高效制备稳定性得到提高的季铵盐的方法。
• METHOD FOR STORING QUATERNARY AMMONIUM SALT
  申请人：TOKUYAMA CORPORATION

  公开号：EP1178043B1

  公开（公告）日：2005-12-28