摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

Bz3SnOH

中文名称
——
中文别名
——
英文名称
Bz3SnOH
英文别名
tribenzyl tin hydroxide;tribenzyltin(IV) hydroxide;Tribenzylstannanylium;hydroxide
Bz<sub>3</sub>SnOH化学式
CAS
——
化学式
C21H22OSn
mdl
——
分子量
409.115
InChiKey
PWBSKWIDKXONRH-UHFFFAOYSA-M
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.65
  • 重原子数:
    23
  • 可旋转键数:
    6
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.14
  • 拓扑面积:
    1
  • 氢给体数:
    1
  • 氢受体数:
    1

反应信息

  • 作为反应物:
    描述:
    1-金刚烷甲酸Bz3SnOH甲苯 为溶剂, 反应 5.0h, 以75%的产率得到[BzSn(O)(adamantane-1-carboxylate)]6
    参考文献:
    名称:
    类金刚石修饰的亲脂性有机锡(IV)衍生物的合成,结构和体外生物学评价
    摘要:
    一系列组成Me 3 Sn(L 1)(1),Ph 3 Sn(L 1)(2),{[M e 2 Sn(L 1)] 2 O} 2的饰以类金刚石的有机锡(IV)衍生物(3),[BzSn(O)(L 1)] 6(4),Me 3 Sn(L 2)OH 2(5),[Ph 3 Sn(L 2)] n(6),Bu 2 Sn( L 2)2(7),通过使适当的有机锡(IV)前体与任何一种酸形式的脯氨酸反应,制得Bz 2 Sn(L 2)2 OH 2(8)和[BzSn(O)(L 2)] 6(9)。配体金刚烷-1-羧酸(HL 1)和2-(金刚烷-1-基)乙酸(HL 2)或它们的钠盐。化合物1 – 9通过光谱技术进行了表征,包括在非配位溶剂中的119 Sn NMR,用于评估溶液状态结构。的分子和晶体结构通过X射线晶体学确定2 – 8。堆积在很大程度上由疏水相互作用决定,除了晶体6中有Sn … O二级键很明显,在晶体5和8中每个都有O
    DOI:
    10.1016/j.jorganchem.2021.121802
点击查看最新优质反应信息

文献信息

  • Organotin(IV) derivatives containing heteroditopic pyridyl-quinolin-8-olate ligands: Synthesis and structures
    作者:Tushar S. Basu Baul、Anurag Chaurasiya、Banteilang Lyngdoh Nonglait、Antonin Lyčka、Dieter Schollmeyer、Klaus Jurkschat
    DOI:10.1016/j.jorganchem.2021.121898
    日期:2021.8
    Six novel neutral organotin(IV) complexes, viz. [n-Bu2Sn(L4-PyAQ)2] 1, [Bz2Sn(L4-PyAQ)2] 2, [Ph2Sn(L4-PyAQ)2] 3, [Ph2Sn(L3-PyAQ)2] 4, [Bz3Sn(L4-PyAQ)] 5 and [Ph3Sn(L4-PyAQ)] 6 have been synthesized via reactions of 3/4-pyridyl-quinolin-8-ol pro-ligands, with appropriate diorganotin oxide and triorganotin hydroxide precursors, respectively. The compounds 1-6 were characterized in solution by means of
    六种新型中性有机锡 (IV) 配合物,即。[ n- Bu 2 Sn(L 4-PyAQ ) 2 ] 1 , [Bz 2 Sn(L 4-PyAQ ) 2 ] 2 , [Ph 2 Sn(L 4-PyAQ ) 2 ] 3 , [Ph 2 Sn(L 3-PyAQ ) 2 ] 4 , [Bz 3 Sn(L 4-PyAQ )] 5和[Ph 3 Sn(L 4-PyAQ )] 6已经通过 3/4-pyridyl-quinolin-8-ol pro-ligands 与适当的二有机锡氧化物和三有机锡氢氧化物前体的反应合成。化合物1 - 6由NMR光谱法进行表征在溶液中,同时的固态结构1,6,和溶剂化物的2 ·1.5C 6 H ^ 6,3 ·0.25C 6 H ^ 6,2· 4 ·C 6 H 6和5 ·0.5H 2 O通过单晶X射线衍射分析鉴定。在固态中,锡的中心位置为1-2· 4 ·C 6 H 6是六配位的,显示出扭曲的顺式八面体环境。在5
  • Solvent and intermolecular nitrogen coordination dictated formation of self-assembled organostannane-macrocycles based on monomers and coordination polymers with unsymmetrical 5-[(E)-2-(4-pyridyl)-1-diazenyl]-2-hydroxybenzoate ligand: Structural topologies and dimensionality
    作者:Tushar S. Basu Baul、Anurag Chaurasiya、Andrew Duthie、María G. Vasquez-Ríos、Herbert Höpfl
    DOI:10.1016/j.jorganchem.2018.07.028
    日期:2018.10
    the other hand, compound 6 is a two-dimensional (2D) coordination polymer displaying a distorted pentagonal-bipyramidal geometry around the tin atom where four oxygen atoms of two ligand molecules and the nitrogen atom of a ligand constitute the equatorial plane, while the carbon atoms of the n-butyl groups complete the axial positions. The molecules of 6 self assembled to an interesting dimeric tecton
    一系列六种新的有机锡(IV)化合物,即[ n Pr 3 Sn(HL)(MeOH)] 1,[ n Bu 3 Sn(HL)] n 2,[Bz 3 Sn(HL)] n 3, [Ph 3 Sn(HL)] n· nC 6 H 6 4,[Ph 3 Sn(HL)(EtOH)] 5和[ n Bu 2 Sn(L)] n 6通过适当的三-和二-柔性前配体5-[(E)-2-(4-吡啶基)-1-二氮烯基] -2-羟基苯甲酸。它们的固态结构是从单晶X射线衍射数据推导出来的,对于化合物6,还可以通过固态13 C和119 Sn NMR光谱推导得出。由于甲醇/乙醇配位阻止了聚合物的扩散,化合物1和5是单核的。从羧酸基团HL的单齿氧原子-和醇的锡配位氧原子位于轴向位置,而锡R取代基是在赤道位点,限定所述畸变三角-双锥协调多面体。双方1和5形成通过OH溶剂⋯N py氢键相互作用而形成的一维(1D)链,并且在1个SnPr 3基
  • <sup>1</sup>H,<sup>13</sup>C, AND<sup>119</sup>Sn NMR, IR, MASS, THERMAL, AND BIOLOGICAL STUDIES OF ORGANOTIN(IV) DERIVATIVES OF 4-<i>p</i>-(CHLOROPHENYL)-2-PHENYL-5-THIAZOLEACETIC ACID
    作者:Saqib Ali、M. Nawaz Khokhar、M. H. Bhatti、M. Mazhar、M. Tariq Masood、Khadija Shahid、Amin Badshah
    DOI:10.1081/sim-120014856
    日期:2002.9.26
    A series of di- and triorganotin(IV) carboxylates of 4-p(chlorophenyl)-2-phenyl-5-thiazoleacetic acid has been synthesized and characterized by various instrumental techniques such as infrared, H-1, C-13, Sn-119 NMR, mass spectrometry and thermal analysis. These compounds were also tested for their antibacterial and antifungal activities to study their biological significance.
  • Tribenzyltin carboxylates as anticancer drug candidates: Effect on the cytotoxicity, motility and invasiveness of breast cancer cell lines
    作者:Theebaa Anasamy、Chun Keng Thy、Kong Mun Lo、Chin Fei Chee、Swee Keong Yeap、Behnam Kamalidehghan、Lip Yong Chung
    DOI:10.1016/j.ejmech.2016.09.061
    日期:2017.1
    This study seeks to investigate the relationship between the structural modification and bioactivity of a series of tribenzyltin complexes with different ligands and substitutions. Complexation with the N,N-diisopropylcarbamothioylsulfanylacetate or isonicotinate ligands enhanced the anticancer properties of tribenzyltin compounds via delayed cancer cell-cycle progression, caspase-dependent apoptosis induction, and significant reduction in cell motility, migration and invasion. Halogenation of the benzyl ring improved the anticancer effects of the tribenzyltin compounds with the N,N-diisopropylcarbamothioylsulfanylacetate ligand. These compounds also demonstrated far greater anticancer effects and selectivity than cisplatin and doxorubicin, which provides a rationale for their further development as anticancer agents. (C) 2016 Elsevier Masson SAS. All rights reserved.
  • Synthesis, Characterization, and <i>In Vitro</i> Cytotoxicity of Triorganotin 3,5-Di-<i>tert</i>-butyl-4-hydroxybenzoates
    作者:Wenchao Ding、Zhi Liu、Laijin Tian、Xiangao Quan
    DOI:10.1080/15533174.2011.609233
    日期:2012.1.1
    The triorganotin 3,5-di-tert-butyl-4-hydroxybenzoates, 3,5-(t-Bu)(2)-4-HO-C6H2COOSnR3 (R = c-C6H11, 1; C6H5, 2; C6H5CH2, 3; C6H5C(CH3)(2)CH2, 4), have been synthesized and characterized by elemental analysis, IR, and H-1 and C-13 NMR spectra. The crystal structures of 1 and 4 have been determined by X-ray single crystal diffraction and show that the tin atom possesses a distorted tetrahedral geometry. Intermolecular O-H center dot center dot center dot O hydrogen bond in 1 connects neighboring molecules into a cyclic tetramer. The in vitro cytotoxicity of the compounds against the human tumor cell lines A549 was found to be higher than that of cis-platin used clinically.
查看更多

同类化合物

(βS)-β-氨基-4-(4-羟基苯氧基)-3,5-二碘苯甲丙醇 (S)-(-)-7'-〔4(S)-(苄基)恶唑-2-基]-7-二(3,5-二-叔丁基苯基)膦基-2,2',3,3'-四氢-1,1-螺二氢茚 (S)-盐酸沙丁胺醇 (S)-3-(叔丁基)-4-(2,6-二甲氧基苯基)-2,3-二氢苯并[d][1,3]氧磷杂环戊二烯 (S)-2,2'-双[双(3,5-三氟甲基苯基)膦基]-4,4',6,6'-四甲氧基联苯 (S)-1-[3,5-双(三氟甲基)苯基]-3-[1-(二甲基氨基)-3-甲基丁烷-2-基]硫脲 (R)富马酸托特罗定 (R)-(-)-盐酸尼古地平 (R)-(+)-7-双(3,5-二叔丁基苯基)膦基7''-[((6-甲基吡啶-2-基甲基)氨基]-2,2'',3,3''-四氢-1,1''-螺双茚满 (R)-3-(叔丁基)-4-(2,6-二苯氧基苯基)-2,3-二氢苯并[d][1,3]氧杂磷杂环戊烯 (R)-2-[((二苯基膦基)甲基]吡咯烷 (N-(4-甲氧基苯基)-N-甲基-3-(1-哌啶基)丙-2-烯酰胺) (5-溴-2-羟基苯基)-4-氯苯甲酮 (5-溴-2-氯苯基)(4-羟基苯基)甲酮 (5-氧代-3-苯基-2,5-二氢-1,2,3,4-oxatriazol-3-鎓) (4S,5R)-4-甲基-5-苯基-1,2,3-氧代噻唑烷-2,2-二氧化物-3-羧酸叔丁酯 (4-溴苯基)-[2-氟-4-[6-[甲基(丙-2-烯基)氨基]己氧基]苯基]甲酮 (4-丁氧基苯甲基)三苯基溴化磷 (3aR,8aR)-(-)-4,4,8,8-四(3,5-二甲基苯基)四氢-2,2-二甲基-6-苯基-1,3-二氧戊环[4,5-e]二恶唑磷 (2Z)-3-[[(4-氯苯基)氨基]-2-氰基丙烯酸乙酯 (2S,3S,5S)-5-(叔丁氧基甲酰氨基)-2-(N-5-噻唑基-甲氧羰基)氨基-1,6-二苯基-3-羟基己烷 (2S,2''S,3S,3''S)-3,3''-二叔丁基-4,4''-双(2,6-二甲氧基苯基)-2,2'',3,3''-四氢-2,2''-联苯并[d][1,3]氧杂磷杂戊环 (2S)-(-)-2-{[[[[3,5-双(氟代甲基)苯基]氨基]硫代甲基]氨基}-N-(二苯基甲基)-N,3,3-三甲基丁酰胺 (2S)-2-[[[[[[((1R,2R)-2-氨基环己基]氨基]硫代甲基]氨基]-N-(二苯甲基)-N,3,3-三甲基丁酰胺 (2-硝基苯基)磷酸三酰胺 (2,6-二氯苯基)乙酰氯 (2,3-二甲氧基-5-甲基苯基)硼酸 (1S,2S,3S,5S)-5-叠氮基-3-(苯基甲氧基)-2-[(苯基甲氧基)甲基]环戊醇 (1-(4-氟苯基)环丙基)甲胺盐酸盐 (1-(3-溴苯基)环丁基)甲胺盐酸盐 (1-(2-氯苯基)环丁基)甲胺盐酸盐 (1-(2-氟苯基)环丙基)甲胺盐酸盐 (-)-去甲基西布曲明 龙胆酸钠 龙胆酸叔丁酯 龙胆酸 龙胆紫 龙胆紫 齐达帕胺 齐诺康唑 齐洛呋胺 齐墩果-12-烯[2,3-c][1,2,5]恶二唑-28-酸苯甲酯 齐培丙醇 齐咪苯 齐仑太尔 黑染料 黄酮,5-氨基-6-羟基-(5CI) 黄酮,6-氨基-3-羟基-(6CI) 黄蜡,合成物 黄草灵钾盐