Bz₃SnOH

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bz₃SnOH
• 英文别名: tribenzyl tin hydroxide；tribenzyltin(IV) hydroxide；Tribenzylstannanylium;hydroxide
• 化学式: C₂₁H₂₂OSn
• 分子量: 409.115
• InChiKey: PWBSKWIDKXONRH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.65
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-金刚烷甲酸 、 Bz₃SnOH 以 甲苯 为溶剂， 反应 5.0h， 以75%的产率得到[BzSn(O)(adamantane-1-carboxylate)]₆
  参考文献：
  名称：

  类金刚石修饰的亲脂性有机锡（IV）衍生物的合成，结构和体外生物学评价

  摘要：

  一系列组成Me 3 Sn（L 1）（1），Ph 3 Sn（L 1）（2），{[M e 2 Sn（L 1）] 2 O} 2的饰以类金刚石的有机锡（IV）衍生物（3），[BzSn（O）（L 1）] 6（4），Me 3 Sn（L 2）OH 2（5），[Ph 3 Sn（L 2）] n（6），Bu 2 Sn（ L 2）2（7），通过使适当的有机锡（IV）前体与任何一种酸形式的脯氨酸反应，制得Bz 2 Sn（L 2）2 OH 2（8）和[BzSn（O）（L 2）] 6（9）。配体金刚烷-1-羧酸（HL 1）和2-（金刚烷-1-基）乙酸（HL 2）或它们的钠盐。化合物1 – 9通过光谱技术进行了表征，包括在非配位溶剂中的119 Sn NMR，用于评估溶液状态结构。的分子和晶体结构通过X射线晶体学确定2 – 8。堆积在很大程度上由疏水相互作用决定，除了晶体6中有Sn … O二级键很明显，在晶体5和8中每个都有O

  DOI：

  10.1016/j.jorganchem.2021.121802

文献信息

• Organotin(IV) derivatives containing heteroditopic pyridyl-quinolin-8-olate ligands: Synthesis and structures
  作者：Tushar S. Basu Baul、Anurag Chaurasiya、Banteilang Lyngdoh Nonglait、Antonin Lyčka、Dieter Schollmeyer、Klaus Jurkschat

  DOI：10.1016/j.jorganchem.2021.121898

  日期：2021.8

  Six novel neutral organotin(IV) complexes, viz. [n-Bu2Sn(L4-PyAQ)2] 1, [Bz2Sn(L4-PyAQ)2] 2, [Ph2Sn(L4-PyAQ)2] 3, [Ph2Sn(L3-PyAQ)2] 4, [Bz3Sn(L4-PyAQ)] 5 and [Ph3Sn(L4-PyAQ)] 6 have been synthesized via reactions of 3/4-pyridyl-quinolin-8-ol pro-ligands, with appropriate diorganotin oxide and triorganotin hydroxide precursors, respectively. The compounds 1-6 were characterized in solution by means of

  六种新型中性有机锡 (IV) 配合物，即。[ n- Bu 2 Sn(L 4-PyAQ ) 2 ] 1 , [Bz 2 Sn(L 4-PyAQ ) 2 ] 2 , [Ph 2 Sn(L 4-PyAQ ) 2 ] 3 , [Ph 2 Sn(L 3-PyAQ ) 2 ] 4 , [Bz 3 Sn(L 4-PyAQ )] 5和[Ph 3 Sn(L 4-PyAQ )] 6已经通过 3/4-pyridyl-quinolin-8-ol pro-ligands 与适当的二有机锡氧化物和三有机锡氢氧化物前体的反应合成。化合物1 - 6由NMR光谱法进行表征在溶液中，同时的固态结构1,6，和溶剂化物的2 ·1.5C 6 H ^ 6，3 ·0.25C 6 H ^ 6，2· 4 ·C 6 H 6和5 ·0.5H 2 O通过单晶X射线衍射分析鉴定。在固态中，锡的中心位置为1-2· 4 ·C 6 H 6是六配位的，显示出扭曲的顺式八面体环境。在5
• Solvent and intermolecular nitrogen coordination dictated formation of self-assembled organostannane-macrocycles based on monomers and coordination polymers with unsymmetrical 5-[(E)-2-(4-pyridyl)-1-diazenyl]-2-hydroxybenzoate ligand: Structural topologies and dimensionality
  作者：Tushar S. Basu Baul、Anurag Chaurasiya、Andrew Duthie、María G. Vasquez-Ríos、Herbert Höpfl

  DOI：10.1016/j.jorganchem.2018.07.028

  日期：2018.10

  the other hand, compound 6 is a two-dimensional (2D) coordination polymer displaying a distorted pentagonal-bipyramidal geometry around the tin atom where four oxygen atoms of two ligand molecules and the nitrogen atom of a ligand constitute the equatorial plane, while the carbon atoms of the n-butyl groups complete the axial positions. The molecules of 6 self assembled to an interesting dimeric tecton

  一系列六种新的有机锡（IV）化合物，即[ n Pr 3 Sn（HL）（MeOH）] 1，[ n Bu 3 Sn（HL）] n 2，[Bz 3 Sn（HL）] n 3， [Ph 3 Sn（HL）] n· nC 6 H 6 4，[Ph 3 Sn（HL）（EtOH）] 5和[ n Bu 2 Sn（L）] n 6通过适当的三-和二-柔性前配体5-[（E）-2-（4-吡啶基）-1-二氮烯基] -2-羟基苯甲酸。它们的固态结构是从单晶X射线衍射数据推导出来的，对于化合物6，还可以通过固态13 C和119 Sn NMR光谱推导得出。由于甲醇/乙醇配位阻止了聚合物的扩散，化合物1和5是单核的。从羧酸基团HL的单齿氧原子-和醇的锡配位氧原子位于轴向位置，而锡R取代基是在赤道位点，限定所述畸变三角-双锥协调多面体。双方1和5形成通过OH溶剂⋯N py氢键相互作用而形成的一维（1D）链，并且在1个SnPr 3基
• ¹H,¹³C, AND¹¹⁹Sn NMR, IR, MASS, THERMAL, AND BIOLOGICAL STUDIES OF ORGANOTIN(IV) DERIVATIVES OF 4-<i>p</i>-(CHLOROPHENYL)-2-PHENYL-5-THIAZOLEACETIC ACID
  作者：Saqib Ali、M. Nawaz Khokhar、M. H. Bhatti、M. Mazhar、M. Tariq Masood、Khadija Shahid、Amin Badshah

  DOI：10.1081/sim-120014856

  日期：2002.9.26

  A series of di- and triorganotin(IV) carboxylates of 4-p(chlorophenyl)-2-phenyl-5-thiazoleacetic acid has been synthesized and characterized by various instrumental techniques such as infrared, H-1, C-13, Sn-119 NMR, mass spectrometry and thermal analysis. These compounds were also tested for their antibacterial and antifungal activities to study their biological significance.
• Tribenzyltin carboxylates as anticancer drug candidates: Effect on the cytotoxicity, motility and invasiveness of breast cancer cell lines
  作者：Theebaa Anasamy、Chun Keng Thy、Kong Mun Lo、Chin Fei Chee、Swee Keong Yeap、Behnam Kamalidehghan、Lip Yong Chung

  DOI：10.1016/j.ejmech.2016.09.061

  日期：2017.1

  This study seeks to investigate the relationship between the structural modification and bioactivity of a series of tribenzyltin complexes with different ligands and substitutions. Complexation with the N,N-diisopropylcarbamothioylsulfanylacetate or isonicotinate ligands enhanced the anticancer properties of tribenzyltin compounds via delayed cancer cell-cycle progression, caspase-dependent apoptosis induction, and significant reduction in cell motility, migration and invasion. Halogenation of the benzyl ring improved the anticancer effects of the tribenzyltin compounds with the N,N-diisopropylcarbamothioylsulfanylacetate ligand. These compounds also demonstrated far greater anticancer effects and selectivity than cisplatin and doxorubicin, which provides a rationale for their further development as anticancer agents. (C) 2016 Elsevier Masson SAS. All rights reserved.
• Synthesis, Characterization, and <i>In Vitro</i> Cytotoxicity of Triorganotin 3,5-Di-<i>tert</i>-butyl-4-hydroxybenzoates
  作者：Wenchao Ding、Zhi Liu、Laijin Tian、Xiangao Quan

  DOI：10.1080/15533174.2011.609233

  日期：2012.1.1

  The triorganotin 3,5-di-tert-butyl-4-hydroxybenzoates, 3,5-(t-Bu)(2)-4-HO-C6H2COOSnR3 (R = c-C6H11, 1; C6H5, 2; C6H5CH2, 3; C6H5C(CH3)(2)CH2, 4), have been synthesized and characterized by elemental analysis, IR, and H-1 and C-13 NMR spectra. The crystal structures of 1 and 4 have been determined by X-ray single crystal diffraction and show that the tin atom possesses a distorted tetrahedral geometry. Intermolecular O-H center dot center dot center dot O hydrogen bond in 1 connects neighboring molecules into a cyclic tetramer. The in vitro cytotoxicity of the compounds against the human tumor cell lines A549 was found to be higher than that of cis-platin used clinically.