5-(3,4-dihydroxybenzylidene)-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(3,4-dihydroxybenzylidene)-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one
• 英文别名: (5Z)-5-[(3,4-dihydroxyphenyl)methylidene]-3-[2-(4-hydroxyphenyl)ethyl]-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₈H₁₅NO₄S₂
• 分子量: 373.453
• InChiKey: WVLOXYSBRBZHFG-YBEGLDIGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对羟基苯乙胺 在 ammonium acetate 、 溶剂黄146 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 97.0h， 生成 5-(3,4-dihydroxybenzylidene)-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one
  参考文献：
  名称：

  Synthesis of 5-(Het)arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one Derivatives and Study of Their Antitumor and Anti-Inflammatory Activity

  摘要：

  The reaction of aromatic and heteroaromatic aldehydes with 3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one was studied. A series of new 5-(het)arylidene-3[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-ones was obtained. For synthesized compounds, antitumor and anti-inflammatory activity was studied. Hit-compounds were identified that exceeded the known comparison drugs in their action.

  DOI：

  10.1134/s1070363220070063

文献信息

• Synthesis of 5-(Het)arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one Derivatives and Study of Their Antitumor and Anti-Inflammatory Activity
  作者：V. Ya. Horishny、T. I. Chaban、V. S. Matiychuk

  DOI：10.1134/s1070363220070063

  日期：2020.7

  The reaction of aromatic and heteroaromatic aldehydes with 3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one was studied. A series of new 5-(het)arylidene-3[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-ones was obtained. For synthesized compounds, antitumor and anti-inflammatory activity was studied. Hit-compounds were identified that exceeded the known comparison drugs in their action.