Process for Producing Enantiomer of Amlodipine in High Optical Purity
申请人:Gharpure Milind Moreshwar
公开号:US20080262239A1
公开(公告)日:2008-10-23
The present invention relates to a process for preparation of optically pure (S)-amlodipine-L-hemitartrate DMF solvate comprising the steps of treating (R,S) amlodipine base with L-tartaric acid in the presence of dimethyl formamide and a co-solvent. The invention also relates to a process for converting (R) or (S)-amlopidine-L-hemitartrate DMF solvate into their besylates without isolating free chiral amlopidine base after solution.