2-[2-(5-Methyl-1,3-benzoxazol-2-yl)phenoxy]acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-(5-Methyl-1,3-benzoxazol-2-yl)phenoxy]acetic acid
• 化学式: C₁₆H₁₃NO₄
• 分子量: 283.28
• InChiKey: RFFKUZRGBUJGSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS
  申请人：SNU R&DB Foundation

  公开号：EP2497471A2

  公开（公告）日：2012-09-12

  This application relates to a novel benzo-heterocycle derivative and more particularly, it relates a composition for preventing and treating cancer or for inhibiting metastasis comprising benzo-heterocycle derivative or pharmaceutically acceptable salts thereof as an active ingredient. The present inventors confirmed that KRS has an effect on cancer metastasis by facilitating cancer (or tumor) cell migration through interaction with 67LR, and also found that a substance inhibiting the interaction between KRS and 67LR can prevent and treat cancer by inhibiting cancer cell metastasis. Accordingly, the composition of the present invention can inhibit cancer metastasis, and thus provide a novel means for prevention and treatment of cancer.

  本申请涉及一种新型苯并异环衍生物，更具体地说，它涉及一种用于预防和治疗癌症或抑制转移的组合物，其活性成分包括苯并异环衍生物或其药学上可接受的盐。本发明者证实，KRS 通过与 67LR 相互作用促进癌（或肿瘤）细胞迁移，从而对癌症转移产生影响，还发现抑制 KRS 与 67LR 相互作用的物质可以通过抑制癌细胞转移来预防和治疗癌症。因此，本发明的组合物可以抑制癌症转移，从而为癌症的预防和治疗提供了一种新的手段。
• EP2497471B1
  申请人：——

  公开号：EP2497471B1

  公开（公告）日：2015-04-15