(E)-N-Bromodecyl-4-azachalcone bromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-Bromodecyl-4-azachalcone bromide
• 英文别名: (E)-3-[1-(10-bromodecyl)pyridin-1-ium-4-yl]-1-phenylprop-2-en-1-one;bromide
• 化学式: Br*C₂₄H₃₁BrNO
• 分子量: 509.324
• InChiKey: LMTFZIXMDDEVNO-WPDLWGESSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.39
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  21
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,10-二溴癸烷 、 (E)-1-phenyl-3-(pyridin-4-yl)prop-2-en-1-one 以 乙腈 为溶剂， 以80%的产率得到(E)-N-Bromodecyl-4-azachalcone bromide
  参考文献：
  名称：

  Synthesis and antimicrobial properties of N-substituted derivatives of (E)-4-azachalcones

  摘要：

  Syntheses of 11 new N-bromoalkyl substituted bromides of (E)-4-azachalcone and N-o-(m- and p-) halobenzyl substituted halides of (E)-3'-hydroxy-4-azachalcone of antimicrobial activity are reported. Compounds 3d, 3e, 6b, 6c, and 6e reveal good antimicrobial activity against Staphylococcus aureus and Enterococcus faecalis as well as moderate activity against Escherichia coli and Klebsiella pneumoniae. (C) 2001 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01072-2

文献信息

• Synthesis and antimicrobial properties of N-substituted derivatives of (E)-4-azachalcones
  作者：Zdzisława Nowakowska、Elżbieta Wyrzykiewicz、Bogdan Kędzia

  DOI：10.1016/s0014-827x(01)01072-2

  日期：2001.4

  Syntheses of 11 new N-bromoalkyl substituted bromides of (E)-4-azachalcone and N-o-(m- and p-) halobenzyl substituted halides of (E)-3'-hydroxy-4-azachalcone of antimicrobial activity are reported. Compounds 3d, 3e, 6b, 6c, and 6e reveal good antimicrobial activity against Staphylococcus aureus and Enterococcus faecalis as well as moderate activity against Escherichia coli and Klebsiella pneumoniae. (C) 2001 Elsevier Science S.A. All rights reserved.