9-<(1,3-di(imidazol-1-ylcarbonyloxy)-2-propoxy)methyl>guanine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-<(1,3-di(imidazol-1-ylcarbonyloxy)-2-propoxy)methyl>guanine
• 英文别名: 9-[1,3-Bis(imidazol-1-ylcarbonyloxy)-2-propoxymethyl]-guanine；[2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]-3-(imidazole-1-carbonyloxy)propyl] imidazole-1-carboxylate
• 化学式: C₁₇H₁₇N₉O₆
• 分子量: 443.379
• InChiKey: RNRAARLCXUEBEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  183
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  9-<(1,3-di(imidazol-1-ylcarbonyloxy)-2-propoxy)methyl>guanine 生成 [2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]-3-cyclopentyloxycarbonyloxypropyl] cyclopentyl carbonate
  参考文献：
  名称：

  MARTIN, JOHN C.;TIPPIE, MICHAEL A.;MCGEE, DANNY P. C.;VERHEYDEN, JULIEN P+, J. PHARM. SCI., 76,(1987) N 2, 180-184

  摘要：

  DOI：
• 作为产物：
  描述：

  更昔洛韦 生成 9-<(1,3-di(imidazol-1-ylcarbonyloxy)-2-propoxy)methyl>guanine
  参考文献：
  名称：

  MARTIN, JOHN C.;TIPPIE, MICHAEL A.;MCGEE, DANNY P. C.;VERHEYDEN, JULIEN P+, J. PHARM. SCI., 76,(1987) N 2, 180-184

  摘要：

  DOI：

文献信息

• Synthesis and Antiviral Activity of Various Esters of 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
  作者：John C. Martin、Michael A. Tippie、Danny P.C. McGee、Julien P.H. Verheyden

  DOI：10.1002/jps.2600760221

  日期：1987.2

  The synthesis and in vivo biological activity of a series of mono-O-, di-O-, and N2-acyl derivatives of 9-[(1,3-dihydro-2-propoxy)-methyl]guanine (DHPG) are described.

  描述了9-[（1,3-二氢-2-丙氧基）-甲基]鸟嘌呤（DHPG）的一系列单-O-，二-O-和N2-酰基衍生物的合成和体内生物学活性。
• Anti-viral guanine compounds
  申请人：Merck & Co., Inc.

  公开号：US04816447A1

  公开（公告）日：1989-03-28

  9-(1,3-Dihydroxy-2-propoxymethyl)guanine and 9-(2,3-dihydroxy-1-propoxymethyl)guanine have been found to have potent anti-viral activity against herpes viruses. These compounds, their acyl derivatives, their phosphate derivatives and their pharmaceutically acceptable salts, pharmaceutical formulations containing these compounds, the treatment of DNA viral or herpes viral infections with these compounds, method of preparing these compounds, and novel intermediates useful in their preparation are all disclosed. The compounds may be prepared by reaction of the appropriate acetoxymethyl ether with diacetylguanine, followed by deprotection. The acetoxymethyl ethers may be obtained by reaction of glycerol formal with acetic anhydride in the presence of a catalyst.

  9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤和9-(2,3-二羟基-1-丙氧甲基)鸟嘌呤已被发现对疱疹病毒具有强效的抗病毒活性。本文揭示了这些化合物、它们的酰基衍生物、磷酸酯衍生物和药学上可接受的盐、含有这些化合物的药物配方、使用这些化合物治疗DNA病毒或疱疹病毒感染的方法、制备这些化合物的方法以及在其制备中有用的新中间体。这些化合物可以通过将适当的乙酰氧甲基醚与醋酸酰基鸟嘌呤反应，然后去保护基来制备。乙酰氧甲基醚可以通过在催化剂存在下将甘油缩醛与乙酸酐反应来获得。
• Anti-viral guanine derivatives
  申请人：Merck & Co., Inc.

  公开号：EP0074306A2

  公开（公告）日：1983-03-16

  9-(1,3-dihydroxy-2-propoxymethyl)guanine and 9-(2,3-dihydroxy-1-propoxymethyl)guanine have been found to have potent anti-viral activity against herpes viruses. These compounds, their acyl derivatives, their phosphate derivatives and their pharmaceutically acceptable salts, pharmaceutical formulations containing these compounds, the treatment of viral infections with these compounds, methods of preparing these compounds, and novel intermediates useful in their preparation are all disclosed. The compounds may be prepared by reaction of the appropriate acetoxymethyl ether with diacetylguanine, followed by deprotection. The acetoxymethyl ethers may be obtained by reaction of glycerol formal with acetic anhydride in the presence of a catalyst.

  已发现 9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤和 9-(2,3-二羟基-1-丙氧基甲基)鸟嘌呤对疱疹病毒具有很强的抗病毒活性。 现已公开这些化合物、其酰基衍生物、其磷酸盐衍生物及其药学上可接受的盐、含有这些化合物的药物制剂、用这些化合物治疗病毒感染、制备这些化合物的方法以及用于制备这些化合物的新型中间体。 这些化合物可通过适当的乙酰氧甲基醚与二乙酰鸟嘌呤反应，然后进行脱保护来制备。 乙酰氧甲基醚可通过甘油甲醛与乙酸酐在催化剂存在下反应来获得。
• Anti-viral compounds, their preparation and anti-viral compositions
  申请人：Merck & Co., Inc.

  公开号：EP0165164A1

  公开（公告）日：1985-12-18

  9-(1, 3-Dihydroxy-2-propoxymethyl) quanine and 9-(2, 3-dihydroxy-1-propoxymethyl) guanine have been found to have potent anti-viral activity against herpes viruses. These compounds, their acyl derivatieves, their phosphate derivatives and their pharmaceutically acceptable salts, phar-- maceutical formulations containing these compounds, the treatment of DNA viral or herpes viral infections with these compounds, methods of preparing these compounds, and novel intermediates useful in their preparation are all disclosed. The compounds may be prepared by reaction of the appropriate acetoxymethyl ether with diacetyl-quanine, followed by deprotection. The acetoxymethyl ethers may be obtained by reaction of glycerol formal with acetic anhydride in the presence of a catalyst.

  9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤和9-(2,3-二羟基-1-丙氧基甲基)鸟嘌呤已被发现对疱疹病毒具有很强的抗病毒活性。 本文公开了这些化合物、它们的酰基衍生物、它们的磷酸衍生物和它们的药学上可接受的盐、含有这些化合物的药物制剂、用这些化合物治疗DNA病毒或疱疹病毒感染、制备这些化合物的方法以及用于制备这些化合物的新型中间体。 这些化合物可以通过适当的乙酰氧甲基醚与二乙酰基鸟嘌呤反应，然后进行脱保护来制备。 乙酰氧甲基醚可以通过甘油醛与乙酸酐在催化剂存在下反应来获得。
• MARTIN, JOHN C.;TIPPIE, MICHAEL A.;MCGEE, DANNY P. C.;VERHEYDEN, JULIEN P+, J. PHARM. SCI., 76,(1987) N 2, 180-184
  作者：MARTIN, JOHN C.、TIPPIE, MICHAEL A.、MCGEE, DANNY P. C.、VERHEYDEN, JULIEN P+

  DOI：——

  日期：——