O-methyl-N-prop-2-ynylhydroxylamine hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: O-methyl-N-prop-2-ynylhydroxylamine hydrochloride
• 英文别名: N-methoxypropargylamine hydrochloride；O-Methyl-N-(prop-2-yn-1-yl)hydroxylamine hydrochloride；N-methoxyprop-2-yn-1-amine;hydrochloride
• 化学式: C₄H₇NO*ClH
• 分子量: 121.567
• InChiKey: QHHJNHCGLABKOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.19
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  O-methyl-N-prop-2-ynylhydroxylamine hydrochloride 在 sodium hydroxide 作用下， 以 乙醚 、 水 为溶剂， 以95%的产率得到N-methoxypropargylamine
  参考文献：
  名称：

  对3-乙烯基-1,2,4-三嗪的有机催化氮杂-迈克尔反应作为有价值的双功能平台

  摘要：

  空前的催化氮杂-迈克尔加成反应，取代了3-乙烯基-1,2,4-三嗪，作为多米诺共轭物加成反应的反向双电子平台，反电子需求异Diels–Alder / RetroDiels–Alder（ih DA /使用高度酸性的三氟甲酰亚胺作为有机催化剂可实现r DA）反应。基于烷氧基胺亲核试剂的使用，该序列不仅突出了催化氮杂-迈克尔与链烯基氮杂芳烃反应的罕见实例，而且还证明可用于制备一系列与生物有关的四氢-[1,6]-萘啶。

  DOI：

  10.1021/acs.joc.9b00141
• 作为产物：
  描述：

  N-(tertbutoxycarbonyl)-N-(propargyl)methoxyamine 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 3.0h， 以61%的产率得到O-methyl-N-prop-2-ynylhydroxylamine hydrochloride
  参考文献：
  名称：

  对3-乙烯基-1,2,4-三嗪的有机催化氮杂-迈克尔反应作为有价值的双功能平台

  摘要：

  空前的催化氮杂-迈克尔加成反应，取代了3-乙烯基-1,2,4-三嗪，作为多米诺共轭物加成反应的反向双电子平台，反电子需求异Diels–Alder / RetroDiels–Alder（ih DA /使用高度酸性的三氟甲酰亚胺作为有机催化剂可实现r DA）反应。基于烷氧基胺亲核试剂的使用，该序列不仅突出了催化氮杂-迈克尔与链烯基氮杂芳烃反应的罕见实例，而且还证明可用于制备一系列与生物有关的四氢-[1,6]-萘啶。

  DOI：

  10.1021/acs.joc.9b00141

文献信息

• NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME
  申请人：Galleon Pharmaceuticals, Inc.

  公开号：US20150291597A1

  公开（公告）日：2015-10-15

  The present invention includes compositions that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention.

  本发明包括用于预防和/或治疗呼吸控制疾病或疾病的组合物，适用于需要此类治疗的受试者。本发明还包括一种预防和/或治疗受试者呼吸系统疾病或疾病的方法，包括向受试者施用本发明的治疗有效量的组合物。本发明还包括一种预防不稳定或稳定受试者呼吸节律的方法，包括向受试者施用本发明的治疗有效量的组合物。
• Magnetic Glyco-Nanoparticles: A Tool To Detect, Differentiate, and Unlock the Glyco-Codes of Cancer via Magnetic Resonance Imaging
  作者：Kheireddine El-Boubbou、David C. Zhu、Chrysoula Vasileiou、Babak Borhan、Davide Prosperi、Wei Li、Xuefei Huang

  DOI：10.1021/ja100455c

  日期：2010.3.31

  Within cancer, there is a large wealth of diversity, complexity, and information that nature has engineered rendering it challenging to identify reliable detection methods. Therefore, the development of simple and effective techniques to delineate the fine characteristics of cancer cells can have great potential impacts on cancer diagnosis and treatment. Herein, we report a magnetic glyco-nanoparticle (MGNP) based nanosensor system bearing carbohydrates as the ligands, not only to detect and differentiate cancer cells but also to quantitatively profile their carbohydrate binding abilities by magnetic resonance imaging (MRI). Using an array of MGNPs, a range of cells including closely related isogenic tumor cells, cells with different metastatic potential and malignant vs normal cells can be readily distinguished based on their respective "MRI signatures". Furthermore, the information obtained from such studies helped guide the establishment of strongly binding MGNPs as antiadhesive agents against tumors. As the interactions between glycoconjugates and endogenous lectins present on cancer cell surface are crucial for cancer development and metastasis, the ability to characterize and unlock the glyco-code of individual cell lines can facilitate both the understanding of the roles of carbohydrates as well as the expansion of diagnostic and therapeutic tools for cancer.
• [EN] NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME<br/>[FR] NOUVEAUX COMPOSÉS DE MODULATION DE RÉGULATION DE LA RESPIRATION ORALEMENT BIODISPONIBLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2014078575A3

  公开（公告）日：2014-10-16