二乙基环己基氨基乙烯磷 | 20061-84-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 二乙基环己基氨基乙烯磷
• 中文别名: 环己基氨基乙烯基磷酸二乙酯
• 英文名称: diethyl 2-cyclohexylaminovinylphosphonate
• 英文别名: diethyl 2-(cyclohexylimino)ethylphosphonate；(2-cyclohexylamino-vinyl)-phosphonic acid diethyl ester；diethyl cyclohexylaminovinylphosphonate；diethyl 1-(2-cyclohexylaminovinyl)phosphonate；Diethyl (2-(cyclohexylamino)vinyl)phosphonate；N-(2-diethoxyphosphorylethenyl)cyclohexanamine
• CAS: 20061-84-1
• 化学式: C₁₂H₂₄NO₃P
• mdl: MFCD00014287
• 分子量: 261.301
• InChiKey: GCOCYGLSBKOTBU-UHFFFAOYSA-N

物化性质

• 沸点：
  151-152 °C(Press: 0.04 Torr)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  6-甲基-5-庚烯-2-酮 、 二乙基环己基氨基乙烯磷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.25h， 以85%的产率得到柠檬醛
  参考文献：
  名称：

  Two-Carbons Homologation of Methyl Ketones Examplified for the Synthesis of Citral from 6-Methyl-5-hepten-2-one

  摘要：

  New facile syntheses of 3,7-dimethyl-octadien-2,6-al (citral) from homologation of 6-methyl-5-hepten-2-one are reported.

  DOI：

  10.1081/scc-120017196
• 作为产物：
  描述：

  2,2-二乙氧基乙基磷酸二乙酯 在 2percent aq. HCl 作用下， 以 甲醇 为溶剂， 反应 0.17h， 生成 二乙基环己基氨基乙烯磷
  参考文献：
  名称：

  Synthesis and Biological Evaluation of Cycloalkylidene Carboxylic Acids as Novel Effectors of Ras/Raf Interaction

  摘要：

  The protooncogenes Ras and Raf play important roles in signal transduction pathways regulated by mitogen-activated protein kinases. Mutations of Ras that arrest the protein in its active state are frequently implicated in tumor formation. We used Ras and Raf proteins in the yeast two-hybrid system to search for natural or synthesized substances capable of modulating Ras/ Raf interaction by specifically binding to one of the interacting partners. We found that cycloalkylidene carboxylic acids enhanced Ras/Raf interaction by acting on the cysteine-rich domain of Raf. Several analogues of the active substance 2-cyclohexylidene propanoic acid were synthesized and the importance of the semicyclic double bond in the stabilization of Ras/Raf interaction was demonstrated. Variation of the size and the substituents of the cyclic system as well as the length of the carboxylic acid resulted in enhanced Ras/Raf interaction.

  DOI：

  10.1021/jm011101q
• 作为试剂：
  描述：

  二乙基环己基氨基乙烯磷 、 2,6-diisopropyl-4-(4-fluorophenyl)-5-methoxymethyl-pyridine-3-carbaldehyde 在 二乙基环己基氨基乙烯磷 作用下， 生成 (2E)-3-[4-(4-氟苯基)-2,6-二异丙基-5-(甲氧基甲基)-3-吡啶基]丙烯醛
  参考文献：
  名称：

  Drug. Future 1994, 19, 537

  摘要：

  DOI：

文献信息

• A novel synthesis of didehydroamino acid esters from azomethine ylides
  作者：Paul W. Groundwater、Toqir Sharif、Andrea Arany、David E. Hibbs、Michael B. Hursthouse、Ian Garnett、Miklós Nyerges

  DOI：10.1039/a803695k

  日期：——

  A novel synthesis of didehydroamino acid (DDAA) esters 5 is described, starting from aldimines 2. The mechanism for this reaction has been shown to involve the cycloaddition of an azomethine ylide 3 to an imine 2, followed by the base-catalysed ring-opening of the resulting imidazolidine intermediate 7. This novel method has also been extended to the synthesis of DDAA esters 5 catalysed by imines.

  报道了一种新颖的双脱氢氨基酸酯(DDAA) 5的合成方法，起始原料为醛亚胺2。该反应的机理已被证实涉及偶氮甲碱叶立德3与亚胺2的环加成反应，随后是经碱催化的所得咪唑烷中间体7的环打开过程。这一新方法还扩展到了在亚胺催化下合成DDAA酯5的过程。
• Novel phenylethylene derivatives, processes for preparing the same and intermediates therefor
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0430129A3

  公开（公告）日：1992-02-26

  A novel phenylethylene derivative of the formula: wherein R¹ is phenyl group, a fluorophenyl group, a methoxyphenyl group, thienyl group, furyl group, oxopyrrolidinyl group or pyridyl group, or a pharmaceutically acceptable ester, amide, lactone or salt, which has excellent HMG-CoA reductase inhibitory activity and is useful as an anti-hyperlipidemic agent, a pharmaceutical composition containing the same, and processes for preparing the same as well as an intermediate therefor.

  一种新的苯乙烯衍生物，其化学式为：其中R¹是苯基、氟苯基、甲氧基苯基、噻吩基、呋喃基、氧代吡咯烷基或吡啶基，或其药学上可接受的酯、酰胺、内酯或盐，具有优异的HMG-CoA还原酶抑制活性，可用作抗高脂血症药物，包含该药物的制药组合物以及制备该药物的方法和中间体。
• Substituted pyridyl-dihydroxy-heptenoic acid and its salts
  申请人：Bayer Aktiengesellschaft

  公开号：US05177080A1

  公开（公告）日：1993-01-05

  Substituted pyridyl-dihydroxy-heptenoic acid of the formula ##STR1## and its salts, if desired in an isomeric form, have a superior inhibitory action on HMG-CoA reductase and thus bring about a surprisingly good lowering of the cholesterol content in the blood.

  式为##STR1##的取代吡啶基-双羟基庚烯酸及其盐，如需要以异构形式存在，具有优异的HMG-CoA还原酶抑制作用，从而使血液中的胆固醇含量出乎意料地降低。
• Certain 7-[2,6-diisopropyl-4-phenyl-5-lower
  申请人：Bayer Aktiengesellschaft

  公开号：US05006530A1

  公开（公告）日：1991-04-09

  Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings, X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, and R is ##STR2## wherein R.sup.21 denotes hydrogen or alkyl and R.sup.22 denotes hydrogen, denotes alkyl, aryl or aralkyl, or denotes a cation, and their oxidation products.

  用于治疗高蛋白血症、脂蛋白血症或动脉硬化的新型化合物的公式为##STR1## 其中A、B、D和E可以有不同的含义，X为--CH.sub.2 --CH.sub.2或--CH.dbd.CH--，R为##STR2## 其中R.sup.21表示氢或烷基，R.sup.22表示氢，表示烷基，芳基或芳基烷基，或表示阳离子，以及它们的氧化产物。
• Substituted pyrido (2,3-d) pyrimidines as intermediates
  申请人：Bayer Aktiengesellschaft

  公开号：US05145959A1

  公开（公告）日：1992-09-08

  Substituted pyrido(2,3-d) pyrimidines of the formula: ##STR1## useful as intermediates for the preparation of MMG-CoA reductase inhibitors.

  公式为##STR1##的取代吡啶并[2,3-d]嘧啶化合物，可用作制备MMG-CoA还原酶抑制剂的中间体。