2-(2-Pentylphenyl)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2-Pentylphenyl)pyridine
• 英文别名: 2-(2-n-pentylphenyl)pyridine；2-(2-Pentyl-phenyl)-pyridine
• 化学式: C₁₆H₁₉N
• 分子量: 225.334
• InChiKey: UKBYHTVYLJNVDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-苯基吡啶 生成 2-(2-Pentylphenyl)pyridine
  参考文献：
  名称：

  Lim Yeong-Gweon, Kim Yong Hae, Kang Jung-Bu, J. Chem. Soc. Chem. Commun, (1994) N 19, S 2267-2268

  摘要：

  DOI：

文献信息

• Ruthenium-Catalyzed Regioselective Direct Alkylation of Arenes with Unactivated Alkyl Halides through CH Bond Cleavage
  作者：Lutz Ackermann、Petr Novák、Rubén Vicente、Nora Hofmann

  DOI：10.1002/anie.200902458

  日期：2009.8.3

  Cut to the chase: A ruthenium complex derived from 1‐adamantyl carboxylate (1‐AdCO2−) enabled highly regioselective intermolecular direct alkylation of arenes with unactivated primary and secondary alkyl halides bearing β‐hydrogen atoms (see scheme; NMP=N‐methylpyrrolidinone).

  切入：钌配合物从1-金刚烷基羧酸酯衍生的（1-ADCO 2 - ）启用与未活化的伯和仲烷基卤化物轴承β氢原子的芳烃高度选择性的分子间直接烷基化（参见方案; NMP = Ñ甲基吡咯烷酮）。
• Rhodium-catalysed regioselective alkylation of the phenyl ring of 2-phenylpyridines with olefins
  作者：Yeong-Gweon Lim、Yong Hae Kim、Jung-Bu Kang

  DOI：10.1039/c39940002267

  日期：——

  2-Phenylpyridines react with olefins react with olefins in the presence of rhodium(I) as a catalyst to give 2-(2-alkylphenyl)pyridines by a regioselective alkylation at the ortho position of the phenyl ring.

  在铑(I)作为催化剂的存在下，2-苯基吡啶与烯烃发生反应，通过在苯基环的正交位置进行区域选择性烷基化，生成 2-(2-烷基苯基)吡啶。
• Regioselective alkylation of 2-phenylpyridines with terminal alkenes via C–H bond activation by a rhodium catalyst
  作者：Yeong-Gweon Lim、Jung-Bu Kang、Yong Hae Kim

  DOI：10.1039/p19960002201

  日期：——

  2-Phenylpyridine 1a reacts with various terminal alkenes in the presence of a rhodium(I) complex catalyst to give the corresponding mono ortho-alkylated products 2a-i and doubly alkylated products 3a-b (9:1), The same reaction using 3-methyl-2-phenylpyridine 1b gives the mono alkylated products 2j-n exclusively under the same reaction conditions due to steric hindrance between the methyl group of the pyridine and the alkyl group of 2j-n.