tetrakis(2-pyridyl)tin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tetrakis(2-pyridyl)tin
• 化学式: C₂₀H₁₆N₄Sn
• 分子量: 431.084
• InChiKey: RISYTEMOGIOKHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tetrakis(2-pyridyl)tin 、 2-Bromo-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one 生成 2-(pyridin-2-yl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
  参考文献：
  名称：

  5-(Pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists

  摘要：

  A new series of 5-(pyridinon-1-yl)indazoles with MCH-1 antagonist activity were synthesized. Potential cardiovascular risk for these compounds was assessed based upon their interaction with the hERG potassium channel in a mini-patch clamp assay. Selected compounds were studied in a 5-day diet-induced obese mouse model to evaluate their potential use as weight loss agents. Structural modification of the 5-(pyridinon-1-yl) indazoles to give 5-(furopyridinon-5-yl) indazoles provided compounds with enhanced pharmacokinetic properties and improved efficacy. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.09.039
• 作为产物：
  描述：

  2-溴吡啶 、 四氯化锡 在 正丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 3.5h， 以34%的产率得到tetrakis(2-pyridyl)tin
  参考文献：
  名称：

  Synthesis, Characterization, and Structures of Tetrakis(2-Pyridyl)Tin Compounds

  摘要：

  Reactions of 2-bromopyridine and 2-bromo-6-methylpyridine with n-BuLi and tin tetrachloride afforded Sn(2-py)(4) (1a) and Sn(6-Me-2-py)(4) (1b), respectively. The identities of the two compounds were unambiguously proved by microanalyses, NMR (H-1, C-13, Sn-119) spetroscopy, and single-crystal X-ray diffraction studies.

  DOI：

  10.1080/10426507.2012.702823