2-methoxy-3-methyl-7-(p-nitrophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-methoxy-3-methyl-7-(p-nitrophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one
• 英文别名: 2-Methoxy-3-methyl-7-(4-nitrophenyl)pyrido[2,3-d]pyrimidin-4-one
• 化学式: C₁₅H₁₂N₄O₄
• 分子量: 312.285
• InChiKey: JLIJUULLMTYXDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-氨基-2-甲氧基-3-甲基-4(3H)-嘧啶酮 以 乙醇 为溶剂， 反应 1.17h， 生成 2-methoxy-3-methyl-7-(p-nitrophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one
  参考文献：
  名称：

  New aspects on the selective synthesis of 7-arylpyrido[2,3-d]pyrimidines

  摘要：

  Pyrido[2,3-d]pyrimidines have been synthesized via a selective cyclocondensation reaction between 6-aminopyrimidines 1 and the Mannich bases, propiophenone hydrochlorides 2. Intermediates for this reaction, such as the Michael addition adduct and the further hydrated pyrido[2,3-d]pyrimidine were isolated to prove the postulated mechanism. NMR analysis of bidimensional experiments allowed to determine unambiguously the process to obtain 7-arylpyrido[2,3-d]pyrimidines. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00433-7

文献信息

• New aspects on the selective synthesis of 7-arylpyrido[2,3-d]pyrimidines
  作者：Jairo Quiroga、Henry Insuasty、Braulio Insuasty、Rodrigo Abonı́a、Justo Cobo、Adolfo Sánchez、Manuel Nogueras

  DOI：10.1016/s0040-4020(02)00433-7

  日期：2002.6

  Pyrido[2,3-d]pyrimidines have been synthesized via a selective cyclocondensation reaction between 6-aminopyrimidines 1 and the Mannich bases, propiophenone hydrochlorides 2. Intermediates for this reaction, such as the Michael addition adduct and the further hydrated pyrido[2,3-d]pyrimidine were isolated to prove the postulated mechanism. NMR analysis of bidimensional experiments allowed to determine unambiguously the process to obtain 7-arylpyrido[2,3-d]pyrimidines. (C) 2002 Elsevier Science Ltd. All rights reserved.