6-oxo-2,6-dihydro-pyrido[2,1-a]isoindole-1-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 6-oxo-2,6-dihydro-pyrido[2,1-a]isoindole-1-carbonitrile
• 英文别名: 6-oxo-2H-pyrido[2,1-a]isoindole-1-carbonitrile
• 化学式: C₁₃H₈N₂O
• 分子量: 208.219
• InChiKey: QUUPUQXUCWTZCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氯-3-氰基吡啶 、 2-甲酰基苯硼酸 在 四(三苯基膦)钯 、 碳酸氢钠 作用下， 以 乙醇 、 甲苯 为溶剂， 以55%的产率得到6-oxo-2,6-dihydro-pyrido[2,1-a]isoindole-1-carbonitrile
  参考文献：
  名称：

  A cascade process toward the synthesis of fused polycyclic dihydropyridines

  摘要：

  The synthesis of fused polycyclic dihydropyridincs was achieved using a cascade process comprising a Suzuki coupling, a nucleophilic cyclization and a hydrogen migration. Several functional groups are tolerated in this reaction and the methodology could be applied with Success to quinoline and isoquinoline derivatives. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.010

文献信息

• A cascade process toward the synthesis of fused polycyclic dihydropyridines
  作者：Victor Mamane、Yves Fort

  DOI：10.1016/j.tetlet.2006.02.010

  日期：2006.4

  The synthesis of fused polycyclic dihydropyridincs was achieved using a cascade process comprising a Suzuki coupling, a nucleophilic cyclization and a hydrogen migration. Several functional groups are tolerated in this reaction and the methodology could be applied with Success to quinoline and isoquinoline derivatives. (c) 2006 Elsevier Ltd. All rights reserved.