3-methoxy-pyridine-2-carbonyl chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-methoxy-pyridine-2-carbonyl chloride
• 英文别名: 3-Methoxypyridine-2-carbonyl chloride；3-methoxypyridine-2-carbonyl chloride
• 化学式: C₇H₆ClNO₂
• 分子量: 171.583
• InChiKey: NJKCLKCXGWZDAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methoxy-pyridine-2-carbonyl chloride 在 sodium azide 作用下， 以 水 、 甲苯 为溶剂， 反应 2.0h， 生成 2-Isocyanato-3-methoxypyridine
  参考文献：
  名称：

  Novel Tetrahydropyrido[1,2-a]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts

  摘要：

  The development of CDK and GSK3 inhibitors has been regarded as a potential therapeutic approach, and a substantial number-of-diverse structures have been reported to inhibit CDKs and GSK-3 beta. in recent years. Only a few molecules have gone through or are currently undergoing clinical trials as CDK and GSK inhibitors. In this paper, we prepared valmerins, a new family containing the tetrahydropyrido[1,2-a]isoindone core. The fused heterocycle was prepared with a straightforward synthesis that was functionalized by a (het)arylurea. Twelve valmerins inhibited the CDK5 and GSK3 with an IC50 < 100 nM. A semiquantitative kinase scoring was realized, and a cellular screening was done. At the end of study, we investigated the in vivo potency of one valmerin. Mice exhibited good tolerance to our lead, which proved its efficacy and clearly blocked tumor growth. Valmerins appear also as good candidates: for further development as anticancer agents.

  DOI：

  10.1021/jm3008536
• 作为产物：
  描述：

  3-甲氧基吡啶-2-甲酸甲酯 在 氢氧化钾 、 草酰氯 作用下， 以 二氯甲烷 为溶剂， 生成 3-methoxy-pyridine-2-carbonyl chloride
  参考文献：
  名称：

  Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold

  摘要：

  Systematic SAR studies on the HTS hit pyridine-2-carboxylic acid thiazol-2-ylamide (PACT) analogues revealed that the scaffold of OCAT is indispensable for the inhibition of type I MetAP. For effective inhibition of the enzyme, the most suitable position to modify is the 3-position of the pyridine ring of PCAT, and the best substituents are those containing O or N atoms connected directly with the pyridine ring. These findings provide useful information for the design and discovery of more potent inhibitors of type I MetAPs. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.034

文献信息

• [EN] TRIAZINE-OXADIAZOLES<br/>[FR] TRIAZINE-OXADIAZOLES
  申请人：NOVARTIS AG

  公开号：WO2012035023A1

  公开（公告）日：2012-03-22

  The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of chronic pain.

  这项发明涉及公式（I）的新衍生物，其中取代基如规范中所定义；制备这种衍生物的方法；包括这种衍生物的药物组合物；将这种衍生物用作药物；将这种衍生物用于治疗慢性疼痛。
• 一种作用于微管蛋白的抗肿瘤药物
  申请人：浙江药苑生物科技有限公司

  公开号：CN108675992B

  公开（公告）日：2020-11-27

  本发明公开了一种作用于微管蛋白的抗肿瘤药物，其结构式为其中，R1、R2、R3、R4各自独立的选自H或者OCH3。经过微管蛋白聚合分析试剂盒测试发现具有很好的微管蛋白抑制活性，经过Bel‑7402肝癌移植瘤小鼠模型实验可以得出，本发明化合物具有抗肿瘤的药物活性，可以用于抗肿瘤药物进行更加深入的研发。
• 一种微管蛋白抑制剂及其在抗肿瘤药物中的 应用
  申请人：浙江药苑生物科技有限公司

  公开号：CN108864053B

  公开（公告）日：2020-12-01

  本发明公开了一种化合物，其结构式为其中，R1、R2、R3、R4各自独立的选自H或OCH3。经过微管蛋白聚合分析试剂盒测试发现具有很好的微管蛋白抑制活性，经过Bel‑7402肝癌移植瘤小鼠模型实验可以得出，本发明化合物具有抗肿瘤的药物活性，可以用于抗肿瘤药物进行更加深入的研发。
• Triazine-oxadiazoles
  申请人：BARKER Oliver

  公开号：US20140051676A1

  公开（公告）日：2014-02-20

  The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of chronic pain.

  该发明涉及公式(I)的新衍生物，其中取代基如规范中所定义；制备这种衍生物的方法；包含这种衍生物的药物组合物；这种衍生物作为药物；这种衍生物用于治疗慢性疼痛。
• Largeron, Martine; Auzeil, Nicolas; Bacque, Eric, Journal of the Chemical Society. Perkin Transactions 2 (2001), 1997, # 3, p. 495 - 501
  作者：Largeron, Martine、Auzeil, Nicolas、Bacque, Eric、Fleury, Maurice-Bernard

  DOI：——

  日期：——