2-(2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid methyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid methyl ester
• 英文别名: 2-(2,6-Dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoesaeure-methylester；Methyl 2-(2,6-dimethoxy-4-methylbenzoyl)-3,5-dimethoxybenzoate；methyl 2-(2,6-dimethoxy-4-methylbenzoyl)-3,5-dimethoxybenzoate
• 化学式: C₂₀H₂₂O₇
• 分子量: 374.39
• InChiKey: GVQMSSXJLNOJFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid methyl ester 在 氢氧化钾 作用下， 生成 2-(2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid
  参考文献：
  名称：

  Fragile X mental retardation protein interacts with TDG

  摘要：

  Fragile X syndrome is the most common form of inherited mental retardation disease, resulting from absent of expression of its disease gene FMR1. To study the function of the fragile X mental retardation protein (FMRP) through protein/protein interaction, a mouse embryo cDNA library was screened by the yeast two-hybrid system. A clone was found to interact specifically with FMRP. The cDNA of this clone ( Genbank accession number af102875) encoded a protein highly homologous to human G/T mismatch-specific DNA thymine glycosylase ( hTDG ). Interactions between various alternatively spliced FMRP isoforms and a series of mTDG deletion proteins were further studied in the yeast two-hybrid system and their interaction amino acid regions were determined. Interaction between FMRP and TDG existed inside exon 13 of FMRP ( amino acid residue 397-425) and around amino acid residue 122-346 of TDG. These results will be helpful to the study of the biological role of FMRP.

  DOI：

  10.1007/bf02887096
• 作为产物：
  描述：

  硫赭曲菌素 、 硫酸二甲酯 在 sodium hydroxide 作用下， 生成 2-(2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid methyl ester
  参考文献：
  名称：

  Fragile X mental retardation protein interacts with TDG

  摘要：

  Fragile X syndrome is the most common form of inherited mental retardation disease, resulting from absent of expression of its disease gene FMR1. To study the function of the fragile X mental retardation protein (FMRP) through protein/protein interaction, a mouse embryo cDNA library was screened by the yeast two-hybrid system. A clone was found to interact specifically with FMRP. The cDNA of this clone ( Genbank accession number af102875) encoded a protein highly homologous to human G/T mismatch-specific DNA thymine glycosylase ( hTDG ). Interactions between various alternatively spliced FMRP isoforms and a series of mTDG deletion proteins were further studied in the yeast two-hybrid system and their interaction amino acid regions were determined. Interaction between FMRP and TDG existed inside exon 13 of FMRP ( amino acid residue 397-425) and around amino acid residue 122-346 of TDG. These results will be helpful to the study of the biological role of FMRP.

  DOI：

  10.1007/bf02887096

文献信息

• Fragile X mental retardation protein interacts with TDG
  作者：Yuting Chen、B. Bardoni、Ming Yu、Ning Zhu、Guanyun Wu、J. L. Mandel、Yan Shen

  DOI：10.1007/bf02887096

  日期：2000.3

  Fragile X syndrome is the most common form of inherited mental retardation disease, resulting from absent of expression of its disease gene FMR1. To study the function of the fragile X mental retardation protein (FMRP) through protein/protein interaction, a mouse embryo cDNA library was screened by the yeast two-hybrid system. A clone was found to interact specifically with FMRP. The cDNA of this clone ( Genbank accession number af102875) encoded a protein highly homologous to human G/T mismatch-specific DNA thymine glycosylase ( hTDG ). Interactions between various alternatively spliced FMRP isoforms and a series of mTDG deletion proteins were further studied in the yeast two-hybrid system and their interaction amino acid regions were determined. Interaction between FMRP and TDG existed inside exon 13 of FMRP ( amino acid residue 397-425) and around amino acid residue 122-346 of TDG. These results will be helpful to the study of the biological role of FMRP.