1,2-dimyristoyl-sn-glycero-3-phospho-2'-(hydroxyethyl)-2',5',7',8'-tetramethyl-6'-hydroxychroman

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,2-dimyristoyl-sn-glycero-3-phospho-2'-(hydroxyethyl)-2',5',7',8'-tetramethyl-6'-hydroxychroman
• 英文别名: 1,2-dimyristoyl-sn-glycero-3-phospho-2'-hydroxyethyl-2',5',7',8'-tetramethyl-6-hydroxy-chroman；[(2R)-3-[hydroxy-[2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethoxy]phosphoryl]oxy-2-tetradecanoyloxypropyl] tetradecanoate
• 化学式: C₄₆H₈₁O₁₀P
• 分子量: 825.117
• InChiKey: PLSJUZQJWVOFOX-CKEPHSIHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.7
• 重原子数：
  57
• 可旋转键数：
  36
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  二肉豆蔻酰磷脂酰胆碱 、 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ethanol 在 acetate buffer 、 calcium chloride 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以48%的产率得到1,2-dimyristoyl-sn-glycero-3-phospho-2'-(hydroxyethyl)-2',5',7',8'-tetramethyl-6'-hydroxychroman
  参考文献：
  名称：

  Antioxidant Activity of a Novel Phosphatidyl Derivative of Vitamin E in Lard and Its Model System

  摘要：

  The antioxidant activity of a novel phosphatidyl derivative of vitamin E [1,2-diacyl-sn-glycero-3-phospho-2'-(hydroxyethyl)-2',5',7',8'-tetramethyl-6'-hydroxychroman; PCh] was investigated. The induction period with PCh was longer than that with the mixture of vitamin E and phosphatidylcholine (PC) when lard was allowed to autoxidize at 60 degrees C in the dark. There was little difference in the antioxidant activities between vitamin E and PCh in an azo compound-induced radical chain reaction of the mixture of methyl linoleate and methyl laurate. However, PCh suppressed the occurrence of ferric ion-induced oxidation of this model oil more efficiently than vitamin E. Therefore; the inhibition of iron-mediated oxidation is likely to be responsible for the superiority of PCh in lard. It is also suggested that the synergistic effect of PC is related to the elevation of vitamin E activity for iron-mediated oxidation.

  DOI：

  10.1021/jf00042a007

文献信息

• US5364564A
  申请人：——

  公开号：US5364564A

  公开（公告）日：1994-11-15
• Antioxidant Activity of a Novel Phosphatidyl Derivative of Vitamin E in Lard and Its Model System
  作者：Takuro Koga、Junji Terao

  DOI：10.1021/jf00042a007

  日期：1994.6

  The antioxidant activity of a novel phosphatidyl derivative of vitamin E [1,2-diacyl-sn-glycero-3-phospho-2'-(hydroxyethyl)-2',5',7',8'-tetramethyl-6'-hydroxychroman; PCh] was investigated. The induction period with PCh was longer than that with the mixture of vitamin E and phosphatidylcholine (PC) when lard was allowed to autoxidize at 60 degrees C in the dark. There was little difference in the antioxidant activities between vitamin E and PCh in an azo compound-induced radical chain reaction of the mixture of methyl linoleate and methyl laurate. However, PCh suppressed the occurrence of ferric ion-induced oxidation of this model oil more efficiently than vitamin E. Therefore; the inhibition of iron-mediated oxidation is likely to be responsible for the superiority of PCh in lard. It is also suggested that the synergistic effect of PC is related to the elevation of vitamin E activity for iron-mediated oxidation.