申请人:Toyo Jozo Kabushiki Kaisha
公开号:US04894453A1
公开(公告)日:1990-01-16
A compound of the formula ##STR1## wherein Q is --CO-- or --CH.sub.2 --, R is hydroxyl, lower alkoxy, halogen, --NH-lower alkylene-OH, --NH-lower alkylene-arylthio, --NH-lower alkylene-halogen, ##STR2## in which ##STR3## is dilower alkylamino, cycloalkylamino, morpholino, ##STR4## in which R.sub.9 is hydrogen, lower alkyl or aryl, R.sub.10 is hydrogen, lower alkyl, hydroxy-lower alkyl, hydroxy-lower alkoxy-lower alkyl or di(aryl)-lower alkyl, m is an integer from 4 to 6, n is 2 or 3, R.sub.1 is alkyl or aryl-lower alkyl, R.sub.2 and R.sub.3 are each lower alkyl, or together form tetramethylene, and R.sub.4 is hydrogen, lower alkyl or aryl, in which aryl is phenyl which is optionally substituted with a group selected from the group consisting of 1-3 halogen, nitro, lower alkyl and lower alkoxy, or a pharmaceutically acceptable salt thereof, inhibits blood platelet aggregation, has vasodilating activity and inhibits lipoperoxide generation.
一种化合物的分子式为##STR1##,其中Q为--CO--或--CH.sub.2--,R为羟基,低烷氧基,卤素,--NH-较低烷基-羟基,--NH-较低烷基-芳硫基,--NH-较低烷基-卤素,##STR2##其中##STR3##为二烷基氨基,环烷基氨基,吗啡啉,##STR4##其中R.sub.9为氢,低烷基或芳基,R.sub.10为氢,低烷基,羟基-低烷基,羟基-低烷氧基-低烷基或二(芳基)-低烷基,m为4至6的整数,n为2或3,R.sub.1为烷基或芳基-低烷基,R.sub.2和R.sub.3分别为低烷基,或者一起形成四亚甲基,R.sub.4为氢,低烷基或芳基,其中芳基为苯基,可以选择地取代为来自1-3卤素,硝基,低烷基和低烷氧基的群,或其药用盐,抑制血小板聚集,具有扩张血管活性并抑制脂质过氧化物生成。