dibutylamine monohydrofluoride | 6776-08-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dibutylamine monohydrofluoride
• 英文别名: di-n-butylamine hydrofluoride；N-Butylbutan-1-amine--hydrogen fluoride (1/1)；N-butylbutan-1-amine;hydrofluoride
• CAS: 6776-08-5
• 化学式: C₈H₂₀N*F
• 分子量: 149.252
• InChiKey: ZMBUORMORUHTIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.85
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  16.6
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  三溴化锑 、 dibutylamine monohydrofluoride 以 异丙醇 为溶剂， 生成 di-n-butylammonium monofluorotribromoantimonate(III)
  参考文献：
  名称：

  Mixed tetrahaloantimonates(III)

  摘要：

  DOI：

  10.1016/0022-1902(81)80379-x
• 作为产物：
  描述：

  全氟辛基磺酰氟 、 二正丁胺 生成 N,N-dibutyloctane-1-sulfonamide 、 dibutylamine monohydrofluoride
  参考文献：
  名称：

  Brown, H. A.; Guenthner, R. A.; La Zarte, J. D., persoenliche Mitteilung

  摘要：

  DOI：

文献信息

• METHOD OF SYNTHESIZING FLUORINE-18 LABELED RADIOPHARMACEUTICALS IN ETHANOL AND WATER
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20150367005A1

  公开（公告）日：2015-12-24

  A method of preparing fluorine-18 labeled radiopharmaceuticals ( 18 F-radiopharmaceuticals) is disclosed. More particularly, the present invention relates to a method of preparing an 18 F-radiopharmaceutical by reacting a salt containing fluorine-18 ( 18 F) with an alkyl halide or an alkyl sulfonate in the presence of water and ethanol to obtain a high yield of the 18 F-radiopharmaceutical. The synthetic method eliminates the use of toxic and/or environmentally-unfriendly organic solvents.

  本发明公开了一种制备氟-18标记的放射性药物（18F-放射性药物）的方法。更具体地说，本发明涉及一种通过在水和乙醇的存在下将含氟-18（18F）的盐与烷基卤化物或烷基磺酸酯反应以获得高产率的18F-放射性药物的制备方法。该合成方法消除了使用有毒和/或环境不友好的有机溶剂的需求。
• PROCESS FOR PREPARING FLUORINATED 1,3-DIOXOLAN 2-ONE
  申请人：Koh Meiten

  公开号：US20110009644A1

  公开（公告）日：2011-01-13

  The present invention provides a process for preparing fluorinated 1,3-dioxolan-2-one by reacting a derivative of 1,3-dioxolan-2-one having halogen atom other than fluorine with an amine hydrofluoride in an organic solvent, and in this preparation process, fluorinated 1,3-dioxolane-2-on can be prepared in a short period of time by liquid-liquid reaction while maintaining high yield, by using a derivative of 1,3-dioxolan-2-one having halogen atom other than fluorine as a starting material and fluorinating the derivative with a fluorinating agent.

  本发明提供了一种制备氟代1,3-二氧杂环己烷-2-酮的方法，该方法通过在有机溶剂中将含有氟以外卤素原子的1,3-二氧杂环己烷-2-酮衍生物与氨基氟化物反应，可在短时间内通过液-液反应制备氟代1,3-二氧杂环戊烷-2-酮，同时保持高收率，通过使用含有氟以外卤素原子的1,3-二氧杂环己烷-2-酮衍生物作为起始物质，并使用氟化试剂对衍生物进行氟化。
• Method for Preparing of Organofluoro Compounds in Alcohol Solvents
  申请人：Moon Dae Hyuk

  公开号：US20080171863A1

  公开（公告）日：2008-07-17

  The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry (FIG. 1 ) as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

  本发明涉及一种制备含有放射性同位素氟-18的有机氟化合物的方法。更具体地，本发明涉及一种通过在化学品（图1）的醇溶剂存在下，将含有放射性同位素氟-18的氟盐与烷基卤或烷基磺酸盐反应，以获得高产率的有机氟化合物的方法。根据本发明的合成反应可以在温和的条件下进行，以获得高产率的有机氟化合物，并且反应时间缩短，因此适用于有机氟化合物的大规模生产。
• METHOD FOR PREPARATION OF ORGANOFLUORO COMPOUNDS IN ALCOHOL SOLVENTS
  申请人：MOON Dae Hyuk

  公开号：US20100113763A1

  公开（公告）日：2010-05-06

  The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [ 18 F]florbetaben or [ 18 F]AV-45 having and , respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

  本发明涉及一种制备含放射性同位素氟-18的有机氟化合物的方法。更具体地说，本发明涉及一种通过在化学式1的醇溶剂存在下，将含放射性同位素氟-18的氟盐与烷基卤化物或烷基磺酸酯反应，以获得高产率的有机氟化合物[18F] florbetaben或[18F] AV-45的方法，其化学式分别为11和12。根据本发明的合成反应可以在温和的条件下进行，以获得高产率的有机氟化合物，并且反应时间缩短，因此适用于有机氟化合物的大规模生产。
• Antistatic, fabric-softening detergent additive
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0000416A1

  公开（公告）日：1979-01-24

  Detergent-compatible antistatic compositions contain a combination of cationic antistatic agents, dispersion inhibitor organic agglomerating agent and watersoluble alkaline salts as discrete particles. Preferred composition also contain certain types of smectite clay to enhance fabric-softening properties.

  与洗涤剂兼容的抗静电组合物含有阳离子抗静电剂、分散抑制剂、有机团聚剂和水溶性碱性盐的离散颗粒组合。优选的组合物还含有某些类型的烟晶石粘土，以增强织物的柔软特性。