1-(2-Fluorophenyl)sulfonyl-4-(4-methoxyphenyl)sulfonylpiperazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Fluorophenyl)sulfonyl-4-(4-methoxyphenyl)sulfonylpiperazine
• 化学式: C₁₇H₁₉FN₂O₅S₂
• 分子量: 414.5
• InChiKey: AKJCHTLSEISZHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Methods of Normalizing Aberrant Glycolytic Metabolism in Cancer Cells
  申请人：The Board of Trustees of the Leland Stanford Junior Unviersity

  公开号：US20210199640A1

  公开（公告）日：2021-07-01

  Viability of cancer cells (e.g., glioblastoma cells) can be reduced by administering mannose to the cancer cells; and applying an alternating electric field with a frequency between 100 and 500 kHz to the cancer cells. Susceptibility to treatment with an alternating electric field can be determined by measuring uptake of a PKM2 probe (e.g., [18F]DASA) before and after treatment with an alternating electric field. Notably, experiments show that the combination of mannose and the alternating electric field produces a synergistic anti-glioblastoma result.