1,4-bis(diphenylmethyl)-2',5'-dimethoxybenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1,4-bis(diphenylmethyl)-2',5'-dimethoxybenzene
• 英文别名: 1,4-bisbenzhydryl-2,5-dimethoxybenzene；1,4-dibenzhydryl-2,5-dimethoxybenzene
• 化学式: C₃₄H₃₀O₂
• 分子量: 470.611
• InChiKey: HXKBIOAXMAHRSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二苯基溴甲烷 、 对苯二甲醚 在 C₁₉H₁₀F₁₂S 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 2.0h， 以42%的产率得到1,4-bis(diphenylmethyl)-2',5'-dimethoxybenzene
  参考文献：
  名称：

  Organocatalytic Friedel–Crafts Benzylation of Heteroaromatic and Aromatic Compounds via an SN1 Pathway

  摘要：

  The Friedel-Crafts-type benzylation of various -excessive heteroaromatic and aromatic compounds with trityl or benzhydryl halides was efficiently promoted by a thiourea catalyst. This is a novel example of thiourea catalysis of aromatic alkylation by way of an S(N)1 pathway.

  DOI：

  10.1055/s-0033-1340343

文献信息

• Microwave-Accelerated Alkylation of Arenes/Heteroarenes with Benzylic Alcohols Using Antimony(III) Chloride as Catalyst: Synthesis of O-Heterocycles
  作者：Sandip Nayak、Prashant Shukla、Manoj Choudhary

  DOI：10.1055/s-0030-1260795

  日期：2011.7

  An efficient protocol for alkylation of electron-rich arenes/heteroarenes with benzylic alcohols under microwave irradiation using antimony(III) chloride as catalyst has been developed. The mild reaction conditions, high yields, operational simplicity, and applicability to various substrates render the approach a useful route for the synthesis of diaryl/triarylalkane. In addition, a new route for the

  已经开发了一种使用氯化锑 (III) 作为催化剂在微波辐射下用苄醇对富含电子的芳烃/杂芳烃进行烷基化的有效方案。温和的反应条件、高产率、操作简单和适用于各种底物使该方法成为合成二芳基/三芳基烷烃的有用途径。此外，还完成了将邻烯基化苯酚转化为官能化 O-杂环的新途径。
• Iron-mediated modular decarboxylative cross-nucleophile coupling
  作者：Grace A. Lutovsky、Samuel N. Gockel、Mark W. Bundesmann、Scott W. Bagley、Tehshik P. Yoon

  DOI：10.1016/j.chempr.2023.04.008

  日期：2023.6

  commercial availability, and structural diversity. Decarboxylative coupling reactions enable versatile functionalization of these feedstock chemicals, but many of the most general methods require prefunctionalization of carboxylic acids with redox-active moieties. These internal oxidants can be costly, their installation impedes rapid library synthesis, and their use results in environmentally problematic

  羧酸因其化学稳定性、商业可用性和结构多样性而成为药物发现的重要组成部分。脱羧偶联反应可以实现这些原料化学品的多功能官能化，但许多最通用的方法需要用氧化还原活性部分对羧酸进行预官能化。这些内氧化剂可能成本高昂，它们的安装阻碍了文库的快速合成，并且它们的使用会产生对环境有问题的有机副产物。我们在此报道了一种由廉价、陆地丰富且无毒的 Fe(III) 盐介导的天然羧酸与亲核偶联配偶体直接脱羧交叉偶联的方法。该方法涉及初始光化学脱羧，然后进行自由基-极性交叉，从而能够构建具有显着通用性的多种碳-碳、碳-氧和碳-氮键。
• Talapatra, Bani; Chakraborty, Syamal; Biswas, Kallolmay, Journal of the Indian Chemical Society, 1998, vol. 75, # 10-12, p. 788 - 794
  作者：Talapatra, Bani、Chakraborty, Syamal、Biswas, Kallolmay、Mondal, Sudipta、Talapatra, Sunil Kumar

  DOI：——

  日期：——
• Organocatalytic Friedel–Crafts Benzylation of Heteroaromatic and Aromatic Compounds via an SN1 Pathway
  作者：Hiyoshizo Kotsuki、Naruhisa Watanabe、Aoi Matsugi、Keiji Nakano、Yoshiyasu Ichikawa

  DOI：10.1055/s-0033-1340343

  日期：——

  The Friedel-Crafts-type benzylation of various -excessive heteroaromatic and aromatic compounds with trityl or benzhydryl halides was efficiently promoted by a thiourea catalyst. This is a novel example of thiourea catalysis of aromatic alkylation by way of an S(N)1 pathway.