(2R)-N-benzyl-2-(4-phenylanilino)propanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-N-benzyl-2-(4-phenylanilino)propanamide
• 化学式: C₂₂H₂₂N₂O
• 分子量: 330.4
• InChiKey: NELGTMPYTFZSPH-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] COMPOSITIONS AND METHODS FOR INHIBITING M PRO PROTEASE ACTIVITY AND FOR PREVENTING AND TREATING SARS-COV-2 INFECTION<br/>[FR] COMPOSITIONS ET MÉTHODES D'INHIBITION DE L'ACTIVITÉ PROTÉASE MPRO ET DE PRÉVENTION ET DE TRAITEMENT D'UNE INFECTION À SARS-COV-2
  申请人：[en]ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

  公开号：WO2022119756A1

  公开（公告）日：2022-06-09

  This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a methyl-acetamido-propanamide structure (e.g..,; Formula I) which function as inhibitors of the SARS-CoV-2 main protease (Mpro), which function as therapeutics for the treatment of viral infection characterized with Mproprotease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with Mproprotease activity and/or expression.