(3S)-1-(2-methylpropyl)pyrrolidine-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3S)-1-(2-methylpropyl)pyrrolidine-3-carbonitrile
• 化学式: C₉H₁₆N₂
• 分子量: 152.24
• InChiKey: YXKJVSMPXUNZLK-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• ANTIBACTERIAL COMPOUNDS
  申请人：Forge Therapeutics, Inc.

  公开号：US20210221796A1

  公开（公告）日：2021-07-22

  Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

  本文提供的是杂环衍生物化合物和包含这些化合物的药物组合物，其对抑制革兰氏阴性菌的生长非常有用。此外，这些化合物和组合物还可用于治疗细菌感染，如尿路感染等。
• [EN] CBL-B MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE CBL-B ET LEURS UTILISATIONS
  申请人：NIMBUS CLIO INC

  公开号：WO2022272248A1

  公开（公告）日：2022-12-29

  The invention provides compounds, compositions thereof, and methods of using the same for the inhibition of Cb1-b, and the treatment of a variety of Cb1-b-mediated diseases, disorders or conditions, associated with modulating the immune system implicating Cb1-b. Compounds are also useful for the study of Cb1-b enzymes in biological and pathological phenomena; the study of ubiquitination occurring in bodily tissues; and the comparative evaluation of new Cb1-b inhibitors or other regulators of cell cycle, DNA repair, differentiation, and innate and adaptive immunity in vitro or in vivo.

  本发明提供了用于抑制 Cb1-b 和治疗各种 Cb1-b 介导的疾病、失调或病症的化合物、其组合物和使用方法，这些疾病、失调或病症与调节涉及 Cb1-b 的免疫系统有关。化合物还可用于研究生物和病理现象中的 Cb1-b 酶；研究身体组织中发生的泛素化；以及比较评估体外或体内新的 Cb1-b 抑制剂或细胞周期、DNA 修复、分化以及先天性和适应性免疫的其他调节剂。
• [EN] ANTIBACTERIAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIBACTÉRIENS
  申请人：FORGE THERAPEUTICS INC

  公开号：WO2020061375A1

  公开（公告）日：2020-03-26

  Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram -negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.