4-methoxybenzyl 7-phenylacetamido-3-methoxymethyl-3-cephem-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 4-methoxybenzyl 7-phenylacetamido-3-methoxymethyl-3-cephem-4-carboxylate
• 英文别名: (4-methoxyphenyl)methyl (6R)-3-(methoxymethyl)-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 化学式: C₂₅H₂₆N₂O₆S
• 分子量: 482.557
• InChiKey: HPJUNTNQUCDQJZ-MQNHUJCZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  aqueous sodium chloride 、 4-methoxybenzyl 7-phenylacetamido-3-methoxymethyl-3-cephem-4-carboxylate 、 五氯化磷 生成 4-methoxybenzyl 7-amino-3-methoxymethyl-3-cephem-4-carboxylate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Orally administrable cephalosporin derivatives, and the production and uses thereof
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP0321364A2

  公开（公告）日：1989-06-21

  As new antibacterial compounds are provided a cephalosporin derivative having the general formula (I) wherein R¹ is a lower alkyl group, a lower alkoxymethyl group or a lower alkenyl group, and R² and R³ are each a hydrogen atom or a lower alkyl group, and pharmaceutically acceptable salt thereof. This new cephalosporin derivative of the formula (I) is useful as an orally administrable antibacterial agent which exhibits an excellent antibacterial activity, high absorbability through the digestive tracts of animal and high urinary recovery thereof.

  提供了一种新的头孢菌素衍生物，其具有通式(I)，其中R¹是低级烷基组、低级烷氧甲基组或低级烯基组，R²和R³各自是氢原子或低级烷基组，以及其药学上可接受的盐。这种通式(I)的新头孢菌素衍生物作为口服抗菌剂具有很高的实用性，它显示出优异的抗菌活性，高吸收性通过动物的消化道，以及高尿液回收率。
• CEPHALOSPORIN CRYSTALS AND PROCESS FOR PRODUCING THE SAME
  申请人：OTSUKA CHEMICAL COMPANY, LIMITED

  公开号：EP0963989A1

  公开（公告）日：1999-12-15

  The object of the invention is to provide cephalosporin crystals which are highly stable for a long period under economical storage conditions. The cephalosporin crystals of the invention are obtainable by crystallizing an oily cephalosporin in a solvent containing an alcohol.

  本发明的目的是提供在经济的储存条件下长期高度稳定的头孢菌素晶体。本发明的头孢菌素晶体可通过在含酒精的溶剂中使油性头孢菌素结晶而获得。
• Cephalosporin crystals and process for their preparation
  申请人：——

  公开号：US20020099206A1

  公开（公告）日：2002-07-25

  The object of the invention is to provide cephalosporin crystals which are highly stable for a long period under economical storage conditions. The cephalosporin crystals of the invention are obtainable by crystallizing an oily cephalosporin in a solvent containing an alcohol.

  本发明的目的是提供在经济的储存条件下长期高度稳定的头孢菌素晶体。本发明的头孢菌素晶体可通过在含酒精的溶剂中使油性头孢菌素结晶而获得。