1,3-bis(3-methylbenzyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-bis(3-methylbenzyl)urea
• 英文别名: 1,3-Bis[(3-methylphenyl)methyl]urea
• 化学式: C₁₇H₂₀N₂O
• 分子量: 268.359
• InChiKey: ZUTGZFNEKNPAGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  potassium phtalimide 在 乙醚 作用下， 生成 1,3-bis(3-methylbenzyl)urea
  参考文献：
  名称：

  Broemme, Chemische Berichte, 1888, vol. 21, p. 2700

  摘要：

  DOI：

文献信息

• Amine‐Responsive Disassembly of Au ^I –Cu ^I Double Salts for Oxidative Carbonylation
  作者：Yanwei Cao、Jian‐Gong Yang、Yi Deng、Shengchun Wang、Qi Liu、Chaoren Shen、Wei Lu、Chi‐Ming Che、Yong Chen、Lin He

  DOI：10.1002/anie.201914089

  日期：2020.1.27

  A sensitive amine-responsive disassembly of self-assembled AuI -CuI double salts was observed and its utilization for the synergistic catalysis was enlightened. Investigation of the disassembly of [Au(NHC)2 ][CuI2 ] revealed the contribution of Cu-assisted ligand exchange of N-heterocyclic carbene (NHC) by amine in [Au(NHC)2 ]+ and the capacity of [CuI2 ]- on the oxidative step. By integrating the

  观察到自组装的AuI-CuI复盐的敏感的胺反应分解，并启发了其在协同催化中的应用。对[Au（NHC）2] [CuI2]的分解研究表明，胺在[Au（NHC）2] +中的铜辅助配位交换了N-杂环卡宾（NHC）和[CuI2]的容量-在氧化步骤上。通过整合编码在d10金属配合物的响应行为和固有催化功能中的暗示信息，开发了一种用于胺的氧化羰基化的催化剂。该方法的优势已在温和的反应条件和明显扩大的范围上得到了明显体现（51个实例）。伯胺和空间仲胺都可以用作底物。金和铜中心的协同反应
• Manganese catalyzed urea and polyurea synthesis using methanol as C1 source
  作者：Jiaxin Guo、Jun Tang、Hui Xi、Sheng-Yin Zhao、Weiping Liu

  DOI：10.1016/j.cclet.2022.08.011

  日期：2023.4

  The manganese-catalyzed dehydrogenative coupling between methanol and amines for the synthesis of ureas and polyureas is described. Importantly, catalytic efficiency can be improved by the newly synthesized MACHO ligands. Furthermore, this highly atom-economical protocol demonstrates a broad substrate scope with good functional group tolerance, producing H2 as the sole byproduct. Mechanistic studies

  描述了用于合成脲和聚脲的甲醇和胺之间的锰催化脱氢偶联。重要的是，新合成的 MACHO 配体可以提高催化效率。此外，这种高度原子经济的方案展示了广泛的底物范围和良好的官能团耐受性，产生 H 2作为唯一的副产物。机理研究表明，甲酰胺是通过锰催化胺与甲醇的甲酰化作用形成的。随后的脱氢提供了一种瞬时异氰酸酯，它被另一当量的胺攻击以提供最终产物。
• Co-N-doped carbon nanotubes supported on diatomite for highly efficient catalysis oxidative carbonylation of amines with CO and air
  作者：Jiangwei Li、Dong-huai Tu、Yani Li、Weiqiang Wang、Qinwei Yu、Jianming Yang、Jian Lu

  DOI：10.1016/j.apcata.2017.09.030

  日期：2018.1

  Cobalt-nitrogen-doped carbon nanotubes stably supported on diatomite were obtained by employing Co(OAc)(2)/phenanthroline. The resulting material was found to be excellent catalysts for the carbonylation of a variety of amines with CO other than phosgene. Both high activity and selectivity were achieved in this carbonylation process, and it allows air as a cheap oxidizing agent. Moreover the catalyst could be recycled for several times with relatively higher activity compared to homogeneous catalyst palladium acetate.
• Broemme, Chemische Berichte, 1888, vol. 21, p. 2700
  作者：Broemme

  DOI：——

  日期：——