(S)-6-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (S)-6-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• 英文别名: (3S)-6-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: FCZMZQBYQJLYMW-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-6-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 在 titanium(IV) isopropylate 、 potassium carbonate 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 7.33h， 生成 (S)-1-(2-(4-methoxyphenyl)-6-methyl-1,2,3,4-tetrahydroisoquinolin-3-yl)cyclopropan-1-ol
  参考文献：
  名称：

  铜催化的好氧氧化环化级联反应构建桥骨架：（-）-Suaveoline的全合成

  摘要：

  基于发现亚铜离子中铜催化的环丙醇开环加成反应的发现，开发了前所未有的催化好氧CH-H氧化/环丙醇环化级联反应，以CuCl 2为多功能催化剂，空气为氧化剂，构建了氮杂双环[3.3。 1]壬烷骨架，广泛存在于天然产物和药物中。使用这种方法，可以实现简明不对称的吲哚生物碱（-）-樟脑碱的全合成。这项研究不仅为构建这种桥接框架提供了一种高效，低成本和环境友好的方法，而且丰富了环丙醇化学和CH功能化的领域。

  DOI：

  10.1002/anie.201902155

文献信息

• [EN] TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS<br/>[FR] INHIBITEURS DE PRMT5 DÉRIVÉS DE TÉTRAHYDROISOQUINOLÉINE
  申请人：CTXT PTY LTD

  公开号：WO2016034673A1

  公开（公告）日：2016-03-10

  A compound of formula I wherein: n is 1 or 2: p is 0 or 1; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; R6a and R6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.

  式I的化合物，其中：n为1或2；p为0或1；R1可选地为一个或多个卤素或甲基基团；R2a和R2b分别选自以下组：(i) F；(ii) H；(iii) Me；和(iv) CH2OH；R2c和R2d分别选自以下组：(i) F；(ii) H；(iii) Me；和(iv) CH2OH；R3a和R3b分别选自H和Me；R4为H或Me；R5为H或Me；R6a和R6b分别选自H和Me；A为(i)可选地取代的苯基；(ii)可选地取代的萘基；或(iii)可选地取代的C5-12杂环基。
• PEPTIDE COMPOUND, APPLICATION THEREOF AND COMPOSITION CONTAINING SAME
  申请人：XDCExplorer (Shanghai) Co., Ltd.

  公开号：EP3647319A1

  公开（公告）日：2020-05-06

  Disclosed in the present invention are a peptide compound, an application thereof, and a composition containing the same. Provided in the present invention are a peptide compound represented by formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a solvate thereof, a crystal form thereof, or a prodrug thereof. The compound has good stability and good activity.         XX0-XX1-XX2-XX3-XX4-XX5-XX6-XX7-XX8-XX9-XX10-P     I

  本发明公开了一种多肽化合物、其应用以及含有该化合物的组合物。本发明提供了一种由式 I 代表的多肽化合物、其药学上可接受的盐、其同系物、其溶液、其晶型或其原药。该化合物具有良好的稳定性和活性。 XX0-XX1-XX2-XX3-XX4-XX5-XX6-XX7-XX8-XX9-XX10-P I
• TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS
  申请人：CTXT PTY LTD

  公开号：US20170298075A1

  公开（公告）日：2017-10-19

  A compound of formula I wherein: n is 1 or 2: p is 0 or 1; R 1 is optionally one or more halo or methyl groups; R 2a and R 2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH 2 OH; R 2c and R 2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH 2 OH; R 3a and R 3b are independently selected from H and Me; R 4 is either H or Me; R 5 is either H or Me; R 6a and R 6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C 5-12 heteroaryl.