5-(6-fluoro-4-oxo-4H-chromen-3-ylmethylene)-pyrimidine-2,4,6-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-(6-fluoro-4-oxo-4H-chromen-3-ylmethylene)-pyrimidine-2,4,6-trione
• 英文别名: Pyrimidine-2,4,6-trione, hexahydro-5-(6-fluoro-4-oxo-4H-chromen-3-ylmethylene)-；5-[(6-fluoro-4-oxochromen-3-yl)methylidene]-1,3-diazinane-2,4,6-trione
• 化学式: C₁₄H₇FN₂O₅
• 分子量: 302.218
• InChiKey: PFCBZDYBKJAILL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  巴比妥酸 、 6-氟色同-3-甲醛 在 D(+)-10-樟脑磺酸 作用下， 以 乙醇 、 水 为溶剂， 反应 0.33h， 以76%的产率得到5-(6-fluoro-4-oxo-4H-chromen-3-ylmethylene)-pyrimidine-2,4,6-trione
  参考文献：
  名称：

  (±)-Camphor-10-sulfonic acid as recyclable and efficient catalyst for the synthesis of some novel coumarin derivatives

  摘要：

  A highly competent-diversity oriented synthesis of coumarin core derivatives using a Knoevenagel condensation followed by Michael addition and subsequent cyclization in the presence of (+/-)-camphor-10-sulfonic acid in a water/ethanol (1:1) solvent system is depicted. Furthermore, easy workup procedures with good yield, rapid reactions with high atom economy, and catalyst recyclability are the fascinating features of the procedure.

  DOI：

  10.1080/00397911.2015.1121281

文献信息

• (±)-Camphor-10-sulfonic acid as recyclable and efficient catalyst for the synthesis of some novel coumarin derivatives
  作者：Digambar Kumbhar、Reshma Patil、Dayanand Patil、Ajinkya Patravale、Dattatray Chandam、Sunetra Jadhav、Madhukar Deshmukh

  DOI：10.1080/00397911.2015.1121281

  日期：2016.1.2

  A highly competent-diversity oriented synthesis of coumarin core derivatives using a Knoevenagel condensation followed by Michael addition and subsequent cyclization in the presence of (+/-)-camphor-10-sulfonic acid in a water/ethanol (1:1) solvent system is depicted. Furthermore, easy workup procedures with good yield, rapid reactions with high atom economy, and catalyst recyclability are the fascinating features of the procedure.