(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl methacrylate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl methacrylate
• 英文别名: Cholesteryl methacrylate；[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 2-methylprop-2-enoate
• 化学式: C₃₁H₅₀O₂
• 分子量: 454.737
• InChiKey: ZHNSYNYLKYUVAH-GTPODGLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dansyl iodide 、 (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl methacrylate 在 三乙胺 作用下， 以 四氯化碳 为溶剂， 反应 48.0h， 以78%的产率得到cholesteryl 2-(dansylmethyl)acrylate
  参考文献：
  名称：

  Novel Trifunctional Building Blocks for Fluorescent Polymers

  摘要：

  [GRAPHICS]Herein, we describe the synthesis of fluorescent 2-(arylsulfonyl)methacrylates and its polymers. These novel trifunctional monomers, possessing a fluorescent arylsulfonyl (ArSO2) group, an alkyl group (R), and a polymerizable olefin, serve as useful building blocks for functionalized fluorescent polymers.

  DOI：

  10.1021/ol035500m
• 作为产物：
  描述：

  胆固醇 、 甲基丙烯酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl methacrylate
  参考文献：
  名称：

  通过调整主链结构和灵活的间隔基长度来自组织胆固醇侧链液晶聚合物

  摘要：

  三种侧链液晶聚合物（SCLCP），其中胆甾醇型液晶元（Chol）与聚丙烯酸酯（PCholAC- m），聚甲基丙烯酸酯（PCholMC- m）和聚（2-乙烯基苯-1,4-二酸酯）连接通过自由基聚合成功地合成了通过不同长度（m = 0、2、4、6、8和10）的亚甲基间隔基形成的（PCholVA- m）主链。使用DSC，POM和SAXS详细研究了聚合物的相行为和结构。结果表明，通过改变主链结构和间隔区长度，Chol-SCLCPs表现出有趣的自组织。所述聚合物最初形成近晶A相，除了没有液晶相的PCholAC-0以外。接下来，聚合物PCholAC-m（m＝ 2、4、6）形成两层近晶A相，其中烷基尾部重叠（SmA 2）。在PCholAC- m（m = 8，10）中观察到两相共存结构，包括双层近晶A相（其中烷基尾部插入到液晶元中）（SmA d）和单层近晶A相，其中液晶元重叠（SmA 1）。对于PCholMC-

  DOI：

  10.1039/c8nj06168h

文献信息

• Self-organization of cholesterol-side-chain liquid crystalline polymers by tailoring the main chain structure and flexible spacer length
  作者：Xiwen Yang、Shaonan Chen、Hang Luo、Haoran Xu、Sheng Chen

  DOI：10.1039/c8nj06168h

  日期：——

  the alkyl tail was overlapped (SmA2). Two-phase coexisting structures were observed in PCholAC-m (m = 8, 10), including a bilayer smectic A phase in which the alkyl tail was inserted into the mesogens (SmAd) and a single-layer smectic A phase in which the mesogens were overlapped (SmA1). Similar results were observed for PCholMC-m. Furthermore, PCholMC-0 possessed a stable bilayer SmA2 owing to the methyl

  三种侧链液晶聚合物（SCLCP），其中胆甾醇型液晶元（Chol）与聚丙烯酸酯（PCholAC- m），聚甲基丙烯酸酯（PCholMC- m）和聚（2-乙烯基苯-1,4-二酸酯）连接通过自由基聚合成功地合成了通过不同长度（m = 0、2、4、6、8和10）的亚甲基间隔基形成的（PCholVA- m）主链。使用DSC，POM和SAXS详细研究了聚合物的相行为和结构。结果表明，通过改变主链结构和间隔区长度，Chol-SCLCPs表现出有趣的自组织。所述聚合物最初形成近晶A相，除了没有液晶相的PCholAC-0以外。接下来，聚合物PCholAC-m（m＝ 2、4、6）形成两层近晶A相，其中烷基尾部重叠（SmA 2）。在PCholAC- m（m = 8，10）中观察到两相共存结构，包括双层近晶A相（其中烷基尾部插入到液晶元中）（SmA d）和单层近晶A相，其中液晶元重叠（SmA 1）。对于PCholMC-
• Cosmetic or dermatological preparations based on emulsifiers which are free from ethylene oxide and propylene oxide, for the preparation of microemulsion gels
  申请人：Beiersdorf AG

  公开号：US06468551B1

  公开（公告）日：2002-10-22

  Microemulsion gels a) based on oil in water type, comprising an oil phase, substantially consisting of not easily volatile constituents, and an aqueous phase containing one or more O/W emulsifiers free from ethylene oxide and propylene oxide and possibly one or more additional O/W emulsifiers, an emulsifier content which is lower than 20 wt. % related to the full weight of the microemulsion, obtained in such a way that a mixture of basic constituents, consisting of an aqueous phase, an oil phase, one or more O/W emulsifiers, possibly one or more additional O/W emulsifiers, possibly other auxiliary, additional or active agents, is made to react against each other in a mixing ratio so that a microemulsion can be obtained and b) in which droplets of discontinuous oil phase are bound to each other by one or more cross-linking substances, whose molecules are characterized by at least one hydrophylic area having a suitable expansion for bridging of distance between each microemulsion droplet and at least one hydropobic area, which can interact hydrophobically with the microemulsion droplets.

  微乳凝胶a)基于水中油型，包括油相，主要由不易挥发的成分组成，以及含有一个或多个不含乙氧基和丙烯氧基的O/W乳化剂的水相，可能还含有一个或多个额外的O/W乳化剂，乳化剂含量低于微乳凝胶的总重量的20重量％，通过使基本成分的混合物相互反应而获得，该混合物包括水相，油相，一个或多个O/W乳化剂，可能还有一个或多个额外的O/W乳化剂，可能还有其他辅助、额外或活性剂，混合比例使微乳凝胶可以获得；b)其中不连续的油相的液滴通过一个或多个交联物质相互结合，这些分子至少具有一个适合于在每个微乳凝胶液滴之间桥接距离的亲水区域和至少一个疏水区域，可以与微乳凝胶液滴发生疏水相互作用。
• [EN] NUCLEIC ACID COMPLEX<br/>[FR] COMPLEXE D'ACIDE NUCLÉIQUE
  申请人：COMMW SCIENT IND RES ORG

  公开号：WO2013003887A1

  公开（公告）日：2013-01-10

  The present invention relates to a complex comprising a cationic block copolymer and a nucleic acid, the cationic block copolymer having at least a tri-block structure comprising a cationic block and two hydrophilic blocks, or a hydrophilic block and two cationic blocks.

  本发明涉及一种包含阳离子嵌段共聚物和核酸的复合物，其中所述阳离子嵌段共聚物至少具有三嵌段结构，包括一个阳离子嵌段和两个亲水性嵌段，或一个亲水性嵌段和两个阳离子嵌段。
• [EN] BRANCHED PEG MOLECULES AND RELATED COMPOSITIONS AND METHODS<br/>[FR] MOLÉCULES DE PEG RAMIFIÉ, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
  申请人：PHASERX INC

  公开号：WO2018126084A1

  公开（公告）日：2018-07-05

  Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

  揭示了分支聚乙二醇（PEG）分子，包括分支PEG-脂质和分支PEG-蛋白质，以及制备分支PEG分子的相关组合物和方法。还公开了相关的组合物、系统和方法，用于体内传递治疗和诊断试剂。
• [EN] THIOCARBONYLTHIO COMPOUNDS AS CHAIN TRANSFER AGENTS SUITABLE FOR RAFT POLYMERIZATION<br/>[FR] COMPOSÉS THIOCARBONYLTHIO EN TANT QU'AGENTS DE TRANSFERT DE CHAÎNE ADAPTÉS POUR LA POLYMÉRISATION EN RADEAU
  申请人：UNIV IOWA STATE RES FOUND INC

  公开号：WO2018009830A1

  公开（公告）日：2018-01-11

  The present invention relates to a compound having the structure of formula (I), wherein R1, R2, R3, R4, R5, R6, and R7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.

  本发明涉及一种具有如下结构的化合物，其中R1、R2、R3、R4、R5、R6和R7如本文所述。本发明还涉及一种制备式(I)化合物的方法，以及一种利用式(I)化合物通过受控自由基聚合合成聚合物的方法。