2,4,7-trimethyl-1,10-phenanthroline | 1644145-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 2,4,7-trimethyl-1,10-phenanthroline
• 英文别名: 2,4,7-Trimethyl-1,10-phenanthroline
• CAS: 1644145-69-6
• 化学式: C₁₅H₁₄N₂
• 分子量: 222.29
• InChiKey: RWHMFNNPBWGBTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  右旋苯甘氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 以 乙腈 为溶剂， 生成 2,4,7-trimethyl-1,10-phenanthroline
  参考文献：
  名称：

  Homolytic aromatic substitution of coordinated ligands. Alkylation of phenanthroline with free radicals from organometals

  摘要：

  DOI：

  10.1021/jo00342a012
• 作为试剂：
  描述：

  酮替芬 、 双三甲基硅氧基甲基硅烷 在 (1,5-cyclooctadiene)(methoxy)iridium(I) dimer 、 2,4,7-trimethyl-1,10-phenanthroline 作用下， 以 四氢呋喃 、 环己烷 为溶剂， 反应 24.0h， 以75%的产率得到5-[Methyl-bis(trimethylsilyloxy)silyl]-2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one
  参考文献：
  名称：

  Iridium-Catalyzed Silylation of Aryl C–H Bonds

  摘要：

  A method for the iridium-catalyzed silylation of aryl C-H bonds is described. The reaction of HSiMe(OSiMe3)(2) with arenes and heteroarenes catalyzed by the combination of [Ir(cod)(OMe)](2) and 2,4,7-trimethylphenanthroline occurs with the aromatic compound as the limiting reagent and with high levels of sterically derived regioselectivity. This new catalytic system occurs with a much higher tolerance for functional groups than the previously reported rhodium-catalyzed silylation of aryl C-H bonds and occurs with a wide range of heteroarenes. The silylarene products are suitable for further transformations, such as oxidation, halogenation, and cross-coupling. Late-stage functionalization of complex pharmaceutical compounds was demonstrated.

  DOI：

  10.1021/ja511352u

文献信息

• [EN] INTERMOLECULAR C-H SILYLATION OF UNACTIVATED ARENES<br/>[FR] SILYLATION C-H INTERMOLÉCULAIRE D'ARÈNES INACTIVÉS
  申请人：UNIV CALIFORNIA

  公开号：WO2015035325A1

  公开（公告）日：2015-03-12

  Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. Exemplary reaction mixtures include the arene substrate, a liganded metal catalyst, a hydrogen acceptor and an organic solvent. The reaction conditions allow for diverse substituents on the arene substrate.

  提供了用于硅基化芳烃底物的反应混合物以及使用这种反应混合物来硅基化芳烃底物的方法。示例反应混合物包括芳烃底物、配体化金属催化剂、氢受体和有机溶剂。反应条件允许芳烃底物上具有多样的取代基。
• MULTI-USE MULTIMODAL IMAGING CHELATES
  申请人：Bornhop Darryl J.

  公开号：US20080241873A1

  公开（公告）日：2008-10-02

  Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester chains, and light harvesting moieties. By changing the chelating ion, phosphoester chain length and/or the light harvesting moiety different imaging techniques, such as MRI, CT, fluorescence and absorption, x-ray and NIR, may be employed to image the tissue cells. Additionally, the cyclen-based chelates may be conjugated to provide for site-specific delivery of the cyclen-based chelate to the desired tissue cells. The cyclen-based chelates may also be delivered to the tissue cells by attaching the cyclen-based to a polymeric delivery vehicle. Although these cyclen-based chelates have a wide variety of application, the preferred use is for imaging of cancer cells, such as brain cancer, for improving resection of a cancerous tissue.

  基于环丙氮（Cyclen）的螯合剂可用作多模态组织细胞成像的对比剂。这些基于环丙氮的螯合剂最好是由1,4,7,10-四氮杂环十二烷（“Cyclen”）形成的多氮杂大环分子，具有不同的螯合离子、磷酸酯链和光收集基团。通过改变螯合离子、磷酸酯链长度和/或光收集基团，可以使用不同的成像技术，如MRI、CT、荧光和吸收、X射线和近红外线来成像组织细胞。此外，可以将基于环丙氮的螯合剂共价结合，以实现对所需组织细胞的位点特异性递送。也可以通过将基于环丙氮的螯合剂连接到聚合物递送载体上来将其递送到组织细胞中。尽管这些基于环丙氮的螯合剂有广泛的应用，但首选用途是用于癌细胞成像，如脑癌，以改善癌组织切除。
• INTERMOLECULAR C-H SILYLATION OF UNACTIVATED ARENES
  申请人：THE REGENTS OF UNIVERSITY OF CALIFORNIA

  公开号：US20160200639A1

  公开（公告）日：2016-07-14

  Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. Exemplary reaction mixtures include the arene substrate, a liganded metal catalyst, a hydrogen acceptor and an organic solvent. The reaction conditions allow for diverse substituents on the arene substrate.

  本文提供了用于硅化芳烃底物的反应混合物及使用这种反应混合物进行硅化芳烃底物的方法。典型的反应混合物包括芳烃底物、配位金属催化剂、氢受体和有机溶剂。反应条件允许在芳烃底物上引入多种取代基。
• CANNABINOID RECEPTOR TARGETED AGENT
  申请人：Bornhop Darryl J.

  公开号：US20090105128A1

  公开（公告）日：2009-04-23

  Compounds of the following formula: wherein X is H or substituted with with at least one X being substituted; and halo is fluorine, chlorine, bromine, iodine; and stereoisomers and conjugable analogs thereof.
• US7338651B2
  申请人：——

  公开号：US7338651B2

  公开（公告）日：2008-03-04