Isosterically designed chiral catalysts: Rationale, optimization and their application in enantioselective nucleophilic addition to aldehydes
作者:En Gao、Qiao Li、Lili Duan、Lin Li、Yue-Ming Li
DOI:10.1016/j.tet.2020.131648
日期:2020.11
enantioselective nucleophilic addition to aldehydes. In the presence of 10 mol% of chiral ligand 1b, enantioselective addition of diethylzinc to aldehydes provided the corresponding secondary alcohols in up to 90% isolated yield and up to 99% ee. Similarly, using 3e as chiral ligand, enantioselective arylation and alkynylation of aldehydes also proceeded readily, leading to the desired chiral alcohols in up to
New C2-symmetric six-membered carbene ligands for asymmetric diethylzinc addition of arylaldehydes
作者:Bihui Zhou、Zijing Li、Chen Yang、Linlin Li、Limei Fan、Hongxia Huang、Jie Li
DOI:10.24820/ark.5550190.p010.410
日期:——
A series of newsix-membered NHC precursors were prepared by simply esterification of their parent compounds. Their applicability in asymmetricdiethylzincaddition of arylaldehydes has been demonstrated and the corresponding secondary alcohol was obtained with good yields and moderate enantioselectivities.
Binaphthyl-based chiral ligands: design, synthesis and evaluation of their performance in enantioselective addition of diethylzinc to aromatic aldehydes
作者:Chao Yao、Piao Wu、Yue Huang、Yaoqi Chen、Lin Li、Yue-Ming Li
DOI:10.1039/d0ob02127j
日期:——
the performance of binaphthyl-based chiral ligands were evaluated with computation and enantioselective addition of diethylzinc to aromatic aldehydes. Under optimized conditions, enantioselective addition of diethylzinc to aromatic aldehydes provided the desired optically active secondary alcohols in high isolated yields (up to 91%) and excellent enantiomericexcesses (up to 98% ee).