二甲基氨基甲酸(2-((二甲基氨基)甲基)-3-吡啶基)酯二盐酸盐 | 67049-84-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 二甲基氨基甲酸(2-((二甲基氨基)甲基)-3-吡啶基)酯二盐酸盐
• 英文名称: Dimethylcarbamic acid (2-((dimethylamino)methyl)-3-pyridyl) ester dihydrochloride
• 英文别名: [2-[(dimethylamino)methyl]pyridin-3-yl] N,N-dimethylcarbamate;dihydrochloride
• CAS: 67049-84-7
• 化学式: C11H19Cl2N3O2
• 分子量: 296.19
• InChiKey: KSQRUYRITNDIRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.79
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  48.1
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
  申请人：Araim Pharmaceuticals, Inc.

  公开号：EP2933264A2

  公开（公告）日：2015-10-21

  The invention provides a pharmaceutical composition for use in a method for preventing, treating, ameliorating or managing cancer or a neoplastic disorder, or for preventing or treating cachexia, wherein the composition comprises an isolated peptide and a pharmaceutically acceptable carrier, wherein the isolated peptide has a length of 14, 15, 16, 17, 18, 19, 20, 21, 23, 24, 25, 26, 27, 28 or 29 amino acids, and wherein the peptide comprises the amino acid sequence of WEHVNAIQEARRLL (SEQ ID NO: 114), or the amino acid sequence WEHVNAIQEARRLL (SEQ ID NO: 114) comprising one or two conservative or non-conservative amino acid substitutions or amino acid equivalents.

  本发明提供了一种用于预防、治疗、改善或控制癌症或肿瘤性疾病，或用于预防或治疗恶病质的方法的药物组合物，其中该组合物包含分离的多肽和药学上可接受的载体，其中分离的多肽具有14、15、16、17、18、19、20、21、23、24、25、26、27、28或29个氨基酸的长度，并且其中该多肽包含WEHVNAIQEARRLL (SEQ ID NO. 114)的氨基酸序列，或包含一个或两个保守或非保守氨基酸取代或氨基酸等价物的氨基酸序列WEHVNAIQEARRLL (SEQ ID NO. 114)，或包含一个或两个保守或非保守氨基酸取代或氨基酸等价物的氨基酸序列WEHVNAIQEARRLL (SEQ ID NO. 114)：114）的氨基酸序列，或包含一个或两个保守或非保守氨基酸取代或氨基酸等价物的氨基酸序列 WEHVNAIQEARRLL（SEQ ID NO: 114）。
• Composite material for tissue restoration
  申请人：The Johns Hopkins University

  公开号：US10463768B2

  公开（公告）日：2019-11-05

  A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

  复合材料可包括凝胶和至少一种置于凝胶中的纳米结构。治疗软组织缺损的方法包括将复合材料应用于软组织缺损，其中复合材料包括凝胶和设置在凝胶中的纳米结构。一种用于愈合软组织缺陷的复合材料的制造方法可以包括提供凝胶并在凝胶中配置纳米纤维。
• Fiber-hydrogel composite surgical meshes for tissue repair
  申请人：The Johns Hopkins University

  公开号：US10471181B2

  公开（公告）日：2019-11-12

  The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

  目前公开的组合物和方法适用于与手术支架或网片集成的水凝胶或纳米纤维-水凝胶复合材料。公开了一种由层状复合材料组成的手术支架装置，目的是减少异物反应，管理组织-材料界面，改善手术网片与受试者周围组织的结合。
• Tissue protective peptides for preventing and treating diseases and disorders associated with tissue damage
  申请人：Araim Pharmaceuticals, Inc.

  公开号：US10864253B2

  公开（公告）日：2020-12-15

  Provided herein are peptides and peptide analogs that have tissue protective activities. The peptides and peptide analogs are useful in preventing and treating a variety of diseases and disorders associated with tissue damage.

  本文提供了具有组织保护活性的肽和肽类似物。这些肽和肽类似物可用于预防和治疗与组织损伤有关的各种疾病和失调。
• Post-surgical imaging marker
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US11191853B2

  公开（公告）日：2021-12-07

  A marker for imaging includes a bio-dissolvable material and a contrast agent configured to provide contrast during an imaging procedure. A method can include forming a marker for imaging from a bio-dissolvable material and impregnating the bio-dissolvable material with a contrast agent. A method can include implanting a bio-dissolvable marker for imaging into a patient.

  用于成像的标记包括生物可溶解材料和造影剂，用于在成像过程中提供对比度。一种方法可以包括用生物可溶解材料形成成像标记，并用造影剂浸渍生物可溶解材料。一种方法可包括将生物可溶解成像标记植入患者体内。