3-benzyl-5-(3-fluorophenyl)-1H-pyrazolo[4,3-c][1,8]-naphthyridin-4(5H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-benzyl-5-(3-fluorophenyl)-1H-pyrazolo[4,3-c][1,8]-naphthyridin-4(5H)-one
• 英文别名: 3-benzyl-5-(3-fluorophenyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4 (5H)-one；3-benzyl-5-(3-fluorophenyl)-2H-pyrazolo[4,3-c][1,8]naphthyridin-4-one
• 化学式: C₂₂H₁₅FN₄O
• 分子量: 370.386
• InChiKey: IZBMLONVLRHYJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  61.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯乙酰氯 在 sodium hydride 、 肼 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 以45%的产率得到3-benzyl-5-(3-fluorophenyl)-1H-pyrazolo[4,3-c][1,8]-naphthyridin-4(5H)-one
  参考文献：
  名称：

  PYRAZOLONAPHTHYRIDINE DERIVATIVE

  摘要：

  公开号：

  EP1559716B1

文献信息

• Pyrazolonaphthyridine derivative
  申请人：Kanazawa Hashime

  公开号：US20060040972A1

  公开（公告）日：2006-02-23

  The target is to provide PDE IV inhibitors which have a highly potent anti-asthmatic and/or COPD-prophylactic/therapeutic profile with unexpectedly excellent safety. A compound of the formula (1): wherein A is phenyl, pyridyl, 1-oxypyridyl, or thienyl, which may be unsubstituted or optionally substituted with one or more members selected from the group consisting of hydroxyl, halogen, cyano, nitro, lower alkyl, lower alkoxy, lower alkylcarbonyloxy, amino, carboxyl, lower alkoxycarbonyl, carboxy-lower alkylene, lower alkoxycarbonyl-lower alkylene, lower alkylsulfonyl, lower alkylsulfonylamino, and ureido; R 1 is a group selected from the group consisting of hydrogen, hydroxyl, halogen, cyano, nitro, lower alkoxy, amino, carboxyl, and lower alkoxycarbonyl; R 2 is hydrogen or lower alkyl; and m is an integer of 1 to 3; or a pharmaceutically acceptable salt thereof, possesses highly excellent PDE IV-specific inhibitory actions and is useful as an anti-asthmatic drug and/or a prophylactic/therapeutic drug for COPD with high safety.

  目标是提供高度有效的PDE IV抑制剂，具有极强的抗哮喘和/或COPD预防/治疗特性，同时具有意外的优异安全性。公式（1）的化合物：其中A为苯基，吡啶基，1-氧代吡啶基或噻吩基，可以是未取代或可选地取代为羟基，卤素，氰基，硝基，低烷基，低烷氧基，低烷基羰氧基，氨基，羧基，低烷氧羰基，羧基-低烷基烯，低烷氧羰基-低烷基烯，低烷基磺酰基，低烷基磺酰胺基和脲基中的一个或多个成员；R1是从氢，羟基，卤素，氰基，硝基，低烷氧基，氨基，羧基和低烷氧羰基中选择的一个基团；R2是氢或低烷基；m是1到3的整数；或其药学上可接受的盐，具有高度优异的PDE IV特异性抑制作用，并可用作高安全性的抗哮喘药物和/或COPD预防/治疗药物。
• Pyrazolonaphthyridine derivatives
  申请人：Kanazawa Hashime

  公开号：US20100093782A1

  公开（公告）日：2010-04-15

  The target is to provide PDE IV inhibitors which have a highly potent anti-asthmatic and/or COPD-prophylactic/therapeutic profile with unexpectedly excellent safety. A compound of the formula (1): wherein A is phenyl, pyridyl, 1-oxypyridyl, or thienyl, which may be unsubstituted or optionally substituted with one or more members selected from the group consisting of hydroxyl, halogen, cyano, nitro, lower alkyl, lower alkoxy, lower alkylcarbonyloxy, amino, carboxyl, lower alkoxy-carbonyl, carboxy-lower alkylene, lower alkoxycarbonyl-lower alkylene, lower alkylsulfonyl, lower alkylsulfonyl-amino, and ureido; R 1 is a group selected from the group consisting of hydrogen, hydroxyl, halogen, cyano, nitro, lower alkoxy, amino, carboxyl, and lower alkoxycarbonyl; R 2 is hydrogen or lower alkyl; and m is an integer of 1 to 3; or a pharmaceutically acceptable salt thereof, possesses highly excellent PDE IV-specific inhibitory actions and is useful as an anti-asthmatic drug and/or a prophylactic/therapeutic drug for COPD with high safety.

  目标是提供具有高度强效的抗哮喘和/或COPD预防/治疗特性以及出乎意料的优异安全性的PDE IV抑制剂。 公式（1）的化合物：其中A是苯基，吡啶基，1-氧代吡啶基或噻吩基，可以是未取代或可选地取代为羟基，卤素，氰基，硝基，低碳基，低烷氧基，低碳酰氧基，氨基，羧基，低烷氧基-羰基，羧基-低烷基，低烷氧基羰基-低烷基，低烷基磺酰基，低烷基磺酰氨基和尿素基中的一种或多种成员; R1是从氢，羟基，卤素，氰基，硝基，低烷氧基，氨基，羧基和低烷氧基羰基中选择的一组基团; R2是氢或低烷基; m是1到3的整数; 或其药学上可接受的盐，具有高度优异的PDE IV特异性抑制作用，并且可用作具有高安全性的抗哮喘药物和/或COPD预防/治疗药物。
• US7608716B2
  申请人：——

  公开号：US7608716B2

  公开（公告）日：2009-10-27