3-oxo-N-(prop-2-en-1-yl)-1,2-benzothiazole-2(3H)-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 3-oxo-N-(prop-2-en-1-yl)-1,2-benzothiazole-2(3H)-carboxamide
• 英文别名: N-allyl-(1,2-benzo[d]isothiazol-3(2H)-one)carboxamide；3-Oxo-3H-benzo[d]isothiazole-2-carboxylic acid allylamide；3-oxo-N-prop-2-enyl-1,2-benzothiazole-2-carboxamide
• 化学式: C₁₁H₁₀N₂O₂S
• 分子量: 234.279
• InChiKey: QTADUAYBQQBCHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2-苯并异噻唑-3-酮 、 3-异氰酸丙烯 以 四氢呋喃 为溶剂， 反应 1.0h， 以67%的产率得到3-oxo-N-(prop-2-en-1-yl)-1,2-benzothiazole-2(3H)-carboxamide
  参考文献：
  名称：

  [EN] BENZISOTHIAZOL-3-ONE-CARBOXYLIC ACID AMIDES AS PHOSPHOLIPASE INHIBITORS
  [FR] AMIDES DE L'ACIDE BENZISOTHIAZOL-3-ONE-CARBOXYLIQUE INHIBITEURS DES PHOSPHOLIPASE

  摘要：

  本发明揭示了一类新的苯并异噻唑-3(2H)-酮化合物，以及利用这些化合物抑制肝脂酶和/或内皮脂酶活性，用于治疗、改善或预防肝脂酶和/或内皮脂酶介导的疾病。

  公开号：

  WO2004094394A1

文献信息

• [EN] BENZISOTHIAZOL-3-ONE-CARBOXYLIC ACID AMIDES AS PHOSPHOLIPASE INHIBITORS<br/>[FR] AMIDES DE L'ACIDE BENZISOTHIAZOL-3-ONE-CARBOXYLIQUE INHIBITEURS DES PHOSPHOLIPASE
  申请人：LILLY CO ELI

  公开号：WO2004094394A1

  公开（公告）日：2004-11-04

  A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated diseases. (I)

  本发明揭示了一类新的苯并异噻唑-3(2H)-酮化合物，以及利用这些化合物抑制肝脂酶和/或内皮脂酶活性，用于治疗、改善或预防肝脂酶和/或内皮脂酶介导的疾病。
• Synthesis and Biological Activity of Acrylate Copolymers Containing 3‐Oxo‐N‐allyl‐1,2‐benzisothiazole‐3(2 <i>H</i> )‐carboxamide Monomer as a Marine Antifouling Coating
  作者：Xuemei Wang、Miao Dong、Zhiping Meng、Junhua Chen、Jianxin Yang、Xianghui Wang

  DOI：10.1002/open.202000273

  日期：2021.5

  nuclear magnetic resonance (NMR) spectroscopies. The inhibitory activities of the copolymers on algae, bacteria, and barnacle larvae were measured, and the antifouling potencies against marine macrofouling organisms were investigated. The results showed that the grafted resin had significant inhibitory effects on the growth of three marine algae (Isochrysis galbana, Nannochloropsisoculata, and Chlorella

  通过甲基丙烯酸甲酯（MMA）与丁基丙烯酸酯共聚，合成了一种含有 3-氧代-N-烯丙基-1,2-苯并异噻唑-2（3 H ）-甲酰胺单体和杂环单体的接枝丙烯酸酯共聚物树脂。丙烯酸酯（BA）与功能单体。单体和共聚物的结构通过红外（IR）和1 H 核磁共振（NMR）光谱进行验证。测量了共聚物对藻类、细菌和藤壶幼虫的抑制活性，并研究了其对海洋大型生物的防污效力。结果表明，接枝树脂对三种海洋藻类（等鞭金藻、微绿绿藻和蛋白核小球藻）和三种细菌（解珊瑚弧菌、金黄色葡萄球菌和副溶血弧菌）的生长具有显着的抑制作用。目标共聚物还表现出对藤壶幼虫存活的优异抑制作用。此外，防污剂的释放速率和海洋现场测试结果表明，接枝共聚物对海洋大型污垢生物的附着具有出色的防污效力。
• Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors
  申请人：Eacho Irving Patrick

  公开号：US20060276522A1

  公开（公告）日：2006-12-07

  A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated diseases. (I)

  本发明揭示了一种新的苯并异噻唑-3(2H)-酮化合物类别，以及使用这些化合物来抑制肝脂酶和/或内皮脂酶活性，以治疗、改善或预防肝脂酶和/或内皮脂酶介导的疾病。(I)
• Sidechain functionalized organosiloxanes, coating compositions containing sidechain functionalized organosiloxanes, coated articles, and methods of making and methods of use thereof
  申请人：Adaptive Surface Technologies, Inc.

  公开号：US11535772B2

  公开（公告）日：2022-12-27

  Sidechain functionalized organosiloxane compounds are provided having a first end and a second end; a polysiloxane backbone; and a first plurality of sidechains covalently attached to the polysiloxane backbone and a second plurality of sidechains covalently attached to the polysiloxane backbone; wherein the first plurality of sidechains comprise polyalkylene glycol sidechains; wherein the first plurality of sidechains and the second plurality of sidechains comprise a tethered end covalently attached to the polysiloxane backbone and a free end opposite to the tethered end; and wherein the free end in one or both of the first plurality of sidechains and the second plurality of sidechains comprises a reactive end group. Compositions comprising the sidechain functionalized organosiloxane compounds are also provided, as well as coated articles. Sidechain functionalized lubricants are also provided that can be used with compositions and coated articles herein.

  侧链官能化有机硅氧烷化合物具有第一端和第二端；聚硅氧烷骨架；以及共价连接至聚硅氧烷骨架的第一多条侧链和共价连接至聚硅氧烷骨架的第二多条侧链；其中第一多条侧链包括聚亚烷基二醇侧链；其中第一多条侧链和第二多条侧链包括与聚硅氧烷骨架共价连接的系链端和与系链端相对的自由端；以及其中第一多条侧链和第二多条侧链中的一条或两条中的自由端包括活性端基。此外，还提供了包含侧链官能化有机硅氧烷化合物的组合物以及涂覆制品。此外，还提供了侧链官能化润滑剂，可与本文所述的组合物和涂覆制品一起使用。
• EP1615900A1
  申请人：——

  公开号：EP1615900A1

  公开（公告）日：2006-01-18