2-aminooctadec-8-ene-1,3-diol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-aminooctadec-8-ene-1,3-diol
• 英文别名: (E)-2-aminooctadec-8-ene-1,3-diol
• 化学式: C₁₈H₃₇NO₂
• 分子量: 299.497
• InChiKey: QFTGJVWBKDHFND-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-aminooctadec-8-ene-1,3-diol 生成 癸醛
  参考文献：
  名称：

  STEIN, J.;BUDZIKIEWICZ, H., Z. NATURFORSCH. B, 43,(1988) N 8, C. 1063-1067

  摘要：

  DOI：
• 作为产物：
  描述：

  2-aminoethyl [(E)-3-hydroxy-2-[(2-hydroxy-15-methylhexadecanoyl)amino]octadec-8-enyl] hydrogen phosphate 生成 2-aminooctadec-8-ene-1,3-diol
  参考文献：
  名称：

  STEIN, J.;BUDZIKIEWICZ, H., Z. NATURFORSCH. B, 43,(1988) N 8, C. 1063-1067

  摘要：

  DOI：

文献信息

• Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
  作者：Xia Lei、Jianmin Li、Bin Liu、Ning Zhang、Haiyang Liu

  DOI：10.3390/molecules200916375

  日期：——

  The Portulaca oleracea L. (P. oleracea) has been used to treat bacillary dysentery for thousands of years in China. Pharmacology studies on P. oleracea have also showed its significant antibacterial effects on the enteropathogenic bacteria, which might reveal the treatment of P. oleracea in cases of bacillary dysentery to some extent. To date, however, the therapeutic basis of P. oleracea treating on bacillary dysentery remains unknown. We determined the antibacterial effective fraction of P. oleracea in a previous study. The current study, which is based on our previous study, was first designed to isolate, identify and screen antibacterial active constituents from P. oleracea. As a result, four new compounds (1–4), portulacerebroside B (1), portulacerebroside C (2), portulacerebroside D (3) and portulaceramide A (4) along with five known compounds (5–9) were isolated, and structures were established by their physico-chemical constants and spectroscopic analysis. The antibacterial activities against common enteropathogenic bacteria were evaluated for all compounds and the new compounds 1–4 showed significant antibacterial effect on enteropathogenic bacteria in vitro, which might contribute to revealing the treatment of P. oleracea in cases of bacillary dysentery.

  马齿苋(Portulaca oleracea L.)在中国数千年以来一直被用作治疗细菌性痢疾。关于马齿苋的药理研究表明它对肠道致病菌有显著的抗菌作用,在一定程度上揭示了马齿苋治疗细菌性痢疾的作用。然而,迄今为止,马齿苋治疗细菌性痢疾的药理基础尚未明确。我们前期研究已确定马齿苋的抗菌有效部位。本研究是在前期研究的基础上,通过分离、鉴定和筛选抗菌活性成分,首次从马齿苋中分离得到4个新的化合物,即马齿苋脑苷脂B(1),马齿苋脑苷脂C(2),马齿苋脑苷脂D(3)和马齿苋酰胺A(4),同时分离得到5个已知化合物(5-9),并通过理化常数和光谱分析确定了它们的结构。并对这些化合物进行抗肠道致病菌活性评价,结果显示,新化合物1-4在体外对肠道致病菌有显著抗菌活性,可能揭示了马齿苋治疗细菌性痢疾的作用机制。
• STEIN, J.;BUDZIKIEWICZ, H., Z. NATURFORSCH. B, 43,(1988) N 8, C. 1063-1067
  作者：STEIN, J.、BUDZIKIEWICZ, H.

  DOI：——

  日期：——