5-Methyl-10-[(methylthio)methyl]-5,10-dihydrodipyrido-[2,3-b:2,3-e]pyrazine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-Methyl-10-[(methylthio)methyl]-5,10-dihydrodipyrido-[2,3-b:2,3-e]pyrazine
• 英文别名: 2-Methyl-9-(methylsulfanylmethyl)-2,4,9,11-tetrazatricyclo[8.4.0.03,8]tetradeca-1(10),3(8),4,6,11,13-hexaene
• 化学式: C₁₃H₁₄N₄S
• 分子量: 258.347
• InChiKey: DJWGWZJRHNLYHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  57.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二甲基二硫 、 5,10-dimethyl-5,10-dihydrodipyrido[2,3-b;2,3-e]pyrazine 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以88%的产率得到5,10-Di-[(methylthio)methyl]-5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazine
  参考文献：
  名称：

  Design of new anticancer drugs. I. Easy hetarynic access to dihydrodipyridopyrazines, a new family of antitumor agents

  摘要：

  Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-bromopyridines in the presence of the complex base NaNH2-tBuONa. A few chemical properties of these new heterocycles are reported, as well as their antitumoral activity. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01558-5

文献信息

• US6127369A
  申请人：——

  公开号：US6127369A

  公开（公告）日：2000-10-03
• Design of new anticancer drugs. I. Easy hetarynic access to dihydrodipyridopyrazines, a new family of antitumor agents
  作者：Ivan Rodriguez、Catherine Kuehm-Caubère、Karine Vinter-Pasquier、Pierre Renard、Bruno Pfeiffer、Paul Caubère

  DOI：10.1016/s0040-4039(98)01558-5

  日期：1998.10

  Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-bromopyridines in the presence of the complex base NaNH2-tBuONa. A few chemical properties of these new heterocycles are reported, as well as their antitumoral activity. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.