triethyl((4-nitrobenzyl)oxy)silane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: triethyl((4-nitrobenzyl)oxy)silane
• 英文别名: (4-nitrobenzyloxy)triethylsilane；Triethyl-[(4-nitrophenyl)methoxy]silane；triethyl-[(4-nitrophenyl)methoxy]silane
• 化学式: C₁₃H₂₁NO₃Si
• 分子量: 267.4
• InChiKey: DWKSEGSBNOQYPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.12
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  对硝基苯甲醇	4-Nitrobenzyl alcohol	619-73-8	C7H7NO3	153.137
  三乙基(苯基甲氧基)硅烷	benzyl triethylsilyl ether	13959-92-7	C13H22OSi	222.403

反应信息

• 作为产物：
  描述：

  triethyl(4-methoxyphenoxy)silane 在 [Ru(κ¹-OAc)(κ²-OAc)(κ³-1,1,1-tris(diphenylphosphinomethyl)ethane)] 作用下， 以 氘代乙腈 、 乙腈 为溶剂， 反应 169.0h， 生成 triethyl((4-nitrobenzyl)oxy)silane
  参考文献：
  名称：

  Silylation of O–H bonds by catalytic dehydrogenative and decarboxylative coupling of alcohols with silyl formates

  摘要：

  Silylformates HCO₂SiR₃首次作为高效的硅烷化剂用于醇类，在钌分子催化剂的存在下。

  DOI：

  10.1039/c7cc05212j

文献信息

• Preparation of Nano Silica Supported Sodium Hydrogen Sulfate: As an Efficient Catalyst for the Trimethyl, Triethyl and<i>t</i>-Butyldimethyl Silylations of Aliphatic and Aromatic Alcohols in Solution and under Solvent-free Conditions
  作者：Abdolreza Abri、Somayeh Ranjdar

  DOI：10.1002/jccs.201300586

  日期：2014.8

  Nano silica supported sodium hydrogen sulfate has been prepared by mixing NaHSO4 with activated Nano silicagel. We wish to report a new method for the synthesis of trimethyl (TMS), triethyl (TES) and t‐butyldimethyl silyl (TBS) ethers from benzylic, allylic, propargylic alcohols, phenols, naphtholes and some of phenolic drugs in the solution and under solvent‐free conditions.

  通过将NaHSO 4与活化的纳米硅胶混合，制备了纳米二氧化硅负载的硫酸氢钠。我们希望报告一种在溶液中和溶液中由苄基，烯丙基，炔丙醇，酚，萘酚和某些酚类药物合成三甲基（TMS），三乙基（TES）和叔丁基二甲基甲硅烷基（TBS）醚的新方法无溶剂条件。
• Ruthenium catalyzed selective hydrosilylation of aldehydes
  作者：Basujit Chatterjee、Chidambaram Gunanathan

  DOI：10.1039/c3cc47593j

  日期：——

  A chemoselective hydrosilylation method for aldehydes is developed using a ruthenium catalyst [(Ru(p-cymene)Cl2)2] and triethylsilane; a mono hydride bridged dinuclear complex [(η6-p-cymene)RuCl}2(μ-H-μ-Cl)] and a Ru(IV) mononuclear dihydride complex [(η6-p-cymene)Ru(H)2(SiEt3)2] are identified as potential intermediates in the reaction and the proposed catalytic cycle involves a 1,3-hydride migration.

  使用钌催化剂[(Ru(p-cymene)Cl2)2]和三乙基硅烷，开发了一种针对醛的化学选择性氢硅烷化方法；鉴定出了单氢桥联双核配合物[(η6-p-cymene)RuCl}2(μ-H-μ-Cl)]和Ru(IV)单核二氢配合物[(η6-p-cymene)Ru(H)2(SiEt3)2]作为反应中潜在的中间体，并且提出的催化循环涉及1,3-氢迁移。
• Use of Silylated Formiates as Hydrosilane Equivalents
  申请人：Commissariat a l'Energie Atomique et aux Energies Alternatives

  公开号：US20210292345A1

  公开（公告）日：2021-09-23

  The present invention relates to a method for preparing organic compounds of formula (I) by reaction between a silylated formiate of formula (II) and an organic compound in the presence of a catalyst and optionally of an additive. The invention also relates to use of the method for preparing organic compounds of formula (I) for the preparation of reagents for fine chemistry and for heavy chemistry, as well as in the production of vitamins, pharmaceutical products, adhesives, acrylic fibres, synthetic leathers, and pesticides.

  本发明涉及一种通过在催化剂和可选添加剂的存在下，使式(I)的有机化合物与式(II)的硅烷基甲酸酯之间发生反应来制备有机化合物的方法。 该发明还涉及利用该方法制备式(I)的有机化合物，用于制备精细化学和重化学的试剂，以及在维生素、药品、粘合剂、丙烯酸纤维、合成皮革和杀虫剂的生产中的用途。
• Carbonyl and olefin hydrosilylation mediated by an air-stable phosphorus(<scp>iii</scp>) dication under mild conditions
  作者：Ryan J. Andrews、Saurabh S. Chitnis、Douglas W. Stephan

  DOI：10.1039/c9cc02460c

  日期：——

  The readily-accessible, air-stable Lewis acid [(terpy)PPh][B(C6F5)4]21 is shown to mediate the hydrosilylation of aldehydes, ketones, and olefins. The utility and mechanism of these hydrosilylations are considered.

  已显示出易于获得的，空气稳定的路易斯酸[（terpy）PPh] [B（C 6 F 5）4 ] 2 1可介导醛，酮和烯烃的氢化硅烷化。考虑了这些氢甲硅烷基化的效用和机理。
• Iron-Catalyzed Silylation of Alcohols by Transfer Hydrosilylation with Silyl Formates
  作者：Thibault Cantat、Timothé Godou、Clément Chauvier、Pierre Thuéry

  DOI：10.1055/s-0036-1591508

  日期：2017.11

  An iron catalyst is shown for the first time to promote transfer hydrosilylation with silyl formates and is utilized for the silylation of alcohols. Attractive features of this protocol include the use of an earth-abundant transition-metal catalyst, mild reaction conditions, and the release of gases as the only byproducts (H 2 and CO 2 ).

  铁催化剂首次被证明可促进甲酸甲硅烷基的转移氢化硅烷化，并用于醇的硅烷化。该协议的吸引人的特点包括使用地球上丰富的过渡金属催化剂、温和的反应条件以及作为唯一副产品 (H 2 和 CO 2 ) 的气体释放。