diethyl (hydroxy(2-hydroxyphenyl)methyl)phosphonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: diethyl (hydroxy(2-hydroxyphenyl)methyl)phosphonate
• 英文别名: diethyl hydroxy(2-hydroxyphenyl)methylphosphonate；diethyl (o,α-dihydroxybenzyl)phosphonate；2-[Diethoxyphosphoryl(hydroxy)methyl]phenol
• 化学式: C₁₁H₁₇O₅P
• 分子量: 260.227
• InChiKey: GYLCZKVOPMBRHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(三甲基硅氧基)苯甲醛 在 水 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 生成 diethyl (hydroxy(2-hydroxyphenyl)methyl)phosphonate
  参考文献：
  名称：

  Nifant'ev, E. E.; Kukhareva, T. S.; Popkova, T. N., Journal of general chemistry of the USSR, 1986, p. 264 - 267

  摘要：

  DOI：

文献信息

• Phospho sulfonic acid: an efficient and recyclable solid acid catalyst for the solvent-free synthesis of α-hydroxyphosphonates and their anticancer properties
  作者：Reddi Mohan Naidu Kalla、Hye Ri Lee、Jiafu Cao、Jin-Wook Yoo、Il Kim

  DOI：10.1039/c5nj00312a

  日期：——

  Some of the title compounds synthesized by a green protocol showed potent anticancer activity.

  一些由绿色合成方法合成的化合物显示出强大的抗癌活性。
• MgO-coated-Fe3O4 nanoparticles as a magnetically recoverable and reusable catalyst for the synthesis of 1-hydroxyphosphonates
  作者：Babak Kaboudin、Foad Kazemi、Fereshteh Habibi

  DOI：10.1007/s13738-014-0504-9

  日期：2015.3

  Nanosize magnetic particles coated with magnesium oxide (core/shell nanoparticles) have been prepared and used for the synthesis of 1-hydroxyalkyl phosphonates. Catalytic activity studies show that the magnetic particles coated with magnesium oxide have highly catalytic activity toward the phosphorylation of aldehydes for the synthesis of 1-hydroxyalkyl phosphonates under solvent-free conditions. Reusability of the prepared magnetic nanoparticles was successfully examined five times with a very slight loss of catalytic activity.

  制备了涂覆有氧化镁的纳米磁性颗粒（核/壳纳米粒子），并用于合成1-羟基烷基磷酸酯。催化活性研究表明，涂覆有氧化镁的磁性颗粒在无溶剂条件下对醛类的磷酸化反应显示出很高的催化活性，用于合成1-羟基烷基磷酸酯。所制备的磁性纳米颗粒经过五次成功的重复使用，催化活性仅有非常轻微的损失。
• Aqueous-Phase Synthesis of<font>α</font>-Hydroxyphosphonates Catalyzed by<font>β</font>-Cyclodextrin
  作者：Katla Ramesh、Bandaru Madhav、Sabbavarapu Narayana Murthy、Yadavalli Venkata Durga Nageswar

  DOI：10.1080/00397911.2010.523492

  日期：2012.1.15

  alpha-Hydroxyphosphonates were synthesized from aromatic/heteroaromatic aldehydes with triethyl phosphite in the presence of beta-cyclodextrin in an aqueous medium. The beta-cyclodextrin can be recovered and reused without loss of catalytic activity.
• NIFANTEV, EH. E.;KUXAREVA, T. S.;POPKOVA, T. N.;DAVYDOCHKINA, O. V., ZH. OBSHCH. XIMII, 1986, 56, N 2, 304-309
  作者：NIFANTEV, EH. E.、KUXAREVA, T. S.、POPKOVA, T. N.、DAVYDOCHKINA, O. V.

  DOI：——

  日期：——