5-tert-butyl-2-(methylthio)thiophene

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-tert-butyl-2-(methylthio)thiophene
• 英文别名: Thiophene, 2-(1,1-dimethylethyl)-5-(methylthio)-；2-tert-butyl-5-methylsulfanylthiophene
• 化学式: C₉H₁₄S₂
• 分子量: 186.342
• InChiKey: WWDONZSFCJHCJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  53.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  dilithium;5,5-dimethylhex-1-en-3-yne-1,1-dithiolate 、 碘甲烷 以42%的产率得到
  参考文献：
  名称：

  DE, JONG, R. L. P.;BRANDSMA, L., J. ORGANOMETAL. CHEM., 1982, 238, N 3, C17-C20

  摘要：

  DOI：

文献信息

• Synthesis of 2,3-disubstituted thiophens via metalated acetylenes and allenes
  作者：R.L.P. De Jong、L. Brandsma

  DOI：10.1016/s0022-328x(00)87040-0

  日期：1982.11

  2,3-Disubstituted thiophen derivatives have been obtained in reasonable yields by treating 2-alkyne- and allene derivatives with butyllithium and potassium t-butoxide in tetrahydrofuran, adding carbon disulfide to the organometallic intermediate and then successively adding t-butyl alcohol, hexamethyl-phosphoric triamide and methyl iodide.

  通过用丁基锂和叔丁醇钾在四氢呋喃中处理2-炔烃和烯丙基衍生物，在有机金属中间体中加入二硫化碳，然后依次加入叔丁醇，六甲基磷酸三酰胺和甲基碘。
• Inhibitors of Histone Deacetylase
  申请人：Moradei Oscar

  公开号：US20080132503A1

  公开（公告）日：2008-06-05

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
• Trichloromethylation and tert-butylation of 2,4-disubstituted thiophenes: Electrophilic substitution reactions with sterically hindered rearomatization stages
  作者：L. I. Belen'kii、G. P. Gromova、B. V. Lichitskii、M. M. Krayushkin

  DOI：10.1007/bf02320327

  日期：1997.11
• BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF
  申请人：Aslanian Robert G.

  公开号：US20100144591A1

  公开（公告）日：2010-06-10

  The present invention relates to compounds of formula (I); compositions comprising the compounds, and methods of using the compounds to treat or prevent pain, diabetes, a diabetic complication, impaired glucose tolerance (IGT) or impaired fasting glucose (IGT) in a patient.