4-phenoxy-N-(2-pyrrolidin-1-ylethyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-phenoxy-N-(2-pyrrolidin-1-ylethyl)benzamide
• 化学式: C₁₉H₂₂N₂O₂
• 分子量: 310.4
• InChiKey: ZRWSCHOWCSJWJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS
  申请人：Amgen, Inc.

  公开号：EP1654225A2

  公开（公告）日：2006-05-10
• EP1654225A4
  申请人：——

  公开号：EP1654225A4

  公开（公告）日：2007-11-28
• Melanin concentrating hormone receptor antagonists
  申请人：Tempest A. Paul

  公开号：US20050256161A1

  公开（公告）日：2005-11-17

  Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula I wherein W, X, Y, Z, R 3 -R 6 , and R 11 are as defined in the specification, are provided. Also provided are methods of treating or preventing a melanin concentrating hormone-mediated disorder in a subject, comprising administering to a subject in need of such treatment or prevention a compound of Formula I.
• [EN] MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR DE L'HORMONE CONCENTRANT LA MELANINE
  申请人：AMGEN INC

  公开号：WO2005019240A2

  公开（公告）日：2005-03-03

  Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula (I) (I) wherein W, X, Y, Z, R3-R6 , and R11 are as defined in the specification, are provided. Also provided are methods of treating or preventing a melanin concentrating hormone-mediated disorder in a subject, comprising administering to a subject in need of such treatment or prevention a compound of Formula I.