7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate
• 英文别名: 3-Hydroxy-8-oxo-7-[(2-phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 化学式: C₁₅H₁₄N₂O₆S
• 分子量: 350.352
• InChiKey: SVOXDJIRULKZTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  p-nitrobenzyl 7-phenoxyacetamido-3-exomethylene-cepham-4-carboxylate 、 p-nitrobenzyl(1R,6R,7R)-7-phenoxyacetamido-3-oxo-3-cepham-4-(R/S)-carboxylate-1-oxide 、 7-phenoxy acetamido-3-hydroxy-3-cephem-4-carboxylate-1(R)-oxide(I) acetamido-7-phenoxyacetamido-3-oxo-3-cepham-4-carboxylate-1(R)-oxide 、 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate 、 异丙醚 、 三氯化磷 生成 para-nitrobenzyl 7-(R)-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Novel c-3 s/o-and s/n formaldehe acetal derivatives of cephalosporins and their use as antibotics
  申请人：——

  公开号：US20040260084A1

  公开（公告）日：2004-12-23

  The compounds of the general formula (I) wherein R 1 denotes a pharmaceutically acceptable side chain radical as used conventionally in the field of cephalosporins and wherein R 2 denotes a pharmaceutically acceptable group which is bonded to the remaining part of the molecule by an oxygen-carbon single bond or a nitrogen-carbon single bond, and their pharmaceutically acceptable salts, esters and amide derivatives are effective antibiotics. 1

  通式（I）的化合物，其中R1表示在头孢菌素领域中惯常使用的药用可接受的侧链基团，而R2表示通过氧-碳单键或氮-碳单键与分子的其余部分连接的药用可接受的基团，以及它们的药用可接受的盐、酯和酰胺衍生物是有效的抗生素。
• NOVEL C-3 S/O- AND S/N FORMALDEHE ACETAL DERIVATIVES OF CEPHALO SPORINS AND THEIR USE AS ANTIBIOTICS
  申请人：Pfaendler, Hans Rudolf

  公开号：EP1444237A1

  公开（公告）日：2004-08-11
• [EN] NOVEL C-3 S/O- AND S/N FORMALDEHE ACETAL DERIVATIVES OF CEPHALO SPORINS AND THEIR USE AS ANTIBIOTICS<br/>[FR] NOUVEAUX DERIVES ACETAL DE FORMALDEHYDE C-3 S/O- ET S/N DE CEPHALOSPORINES ET LEUR UTILISATION EN TANT QU'ANTIBIOTIQUES
  申请人：PFAENDLER HANS RUDOLF

  公开号：WO2003042219A1

  公开（公告）日：2003-05-22

  The compounds of the general formula (I) wherein R1 denotes a pharmaceutically acceptable side chain radical as used conventionally in the field of cephalosporins and wherein R2 denotes a pharmaceutically acceptable group which is bonded to the remaining part of the molecule by an oxygen-carbon single bond or a nitrogen-carbon single bond, and their pharmaceutically acceptable salts, esters and amide derivatives are effective antibiotics.