2-nitro-5-methylthiobenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-nitro-5-methylthiobenzoic acid
• 英文别名: 5-methyl-2-nitrobenzenecarbothioic S-acid
• 化学式: C₈H₇NO₃S
• 分子量: 197.214
• InChiKey: HNFBHYFCPBLLQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 2-nitro-5-methylthiobenzoic acid 以 甲醇 为溶剂， 生成 methyl 2-nitro-5-methylthiobenzoate
  参考文献：
  名称：

  Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of

  摘要：

  本文描述了具有以下结构的吡啶并[2,1-b]喹唑啉的化学式##STR1##其中R.sub.1、R.sub.1'、R.sub.2、R.sub.2'、R.sub.3、R.sub.3'、R.sub.4和R.sub.10如下所述，以及其制备方法。化合物I和II的化学式对于预防过敏反应是有用的。

  公开号：

  US04348396A1
• 作为产物：
  描述：

  甲硫醇 、 5-氯-2-硝基苯甲酸 在 盐酸 作用下， 以 N-甲基乙酰胺 为溶剂， 生成 2-nitro-5-methylthiobenzoic acid
  参考文献：
  名称：

  Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of

  摘要：

  本文描述了具有以下结构的吡啶并[2,1-b]喹唑啉的化学式##STR1##其中R.sub.1、R.sub.1'、R.sub.2、R.sub.2'、R.sub.3、R.sub.3'、R.sub.4和R.sub.10如下所述，以及其制备方法。化合物I和II的化学式对于预防过敏反应是有用的。

  公开号：

  US04348396A1

文献信息

• Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples
  申请人：Chang Chiu Chin

  公开号：US20090263879A1

  公开（公告）日：2009-10-22

  This invention pertains to a method for detecting a compound in the presence of other compounds that are substantially similar in structure and metabolically related to the analyte. The invention is particularly suited for the detection of S-adenosylmethionine in the presence of S-adenosylhomocysteine, other nucleosides and derivatives in a biological sample. The methods of this invention involve an antibody produced specifically against S-adenosylmethionine; particularly, analogs modified strategically at the sulfonium position. An assay protocol comprises chemically modified analyte analog linked to an enzymatic reporter and the aforementioned antibody was used to demonstrate the assay specificity and sensitivity. Additional assay method with immobilized immunogen, the specific antibody, and an enzyme labeled secondary antibody was also described for illustration. The invention also features hapten design and novel compounds used as haptens to prepare immunogen and for the specific antibody production.

  本发明涉及一种在存在结构上与待分析物相似且代谢相关的其他化合物的情况下检测化合物的方法。本发明特别适用于在生物样品中检测S-腺苷甲硫氨酸，尤其是在存在S-腺苷同型半胱氨酸、其他核苷和衍生物的情况下。本发明的方法涉及针对S-腺苷甲硫氨酸特异性产生的抗体，特别是在硫杂环丙烷位点上进行战略性修饰的类似物。检测方案包括化学修饰的待分析物类似物与酶标记的报告物链接，并使用上述抗体来证明检测的特异性和灵敏度。此外，还描述了一种具有固定的免疫原、特异性抗体和酶标记的二级抗体的附加检测方法，以进行说明。本发明还具有半抗原设计和用作半抗原制备免疫原和特异性抗体生产的新化合物。
• ASSAYS AND METHODS FOR SELECTING A TREATMENT REGIMEN FOR A SUBJECT WITH DEPRESSION
  申请人：PAMLAB, L.L.C.

  公开号：US20130267523A1

  公开（公告）日：2013-10-10

  Disclosed herein are novel assays, systems and kits for selecting a treatment regimen for a subject with depression by identifying at least one nucleic acid polymorphism, e.g., but not limited to, at the MTHFR, MTR, or MTRR locus, and/or determining expression levels of peripheral biomarkers (e.g., SAM, SAH, 4-HNE, and/or hsCRP) in a test sample from a human subject. These biomarkers can be used to determine the effectiveness of treating a depressed subject with a folate-containing compound (alone or as an adjunct to an antidepressant). Additionally, these biomarkers can be used to select an appropriate treatment regimen for subjects with treatment-resistant depression (e.g., resistant to at least one selective serotonin reuptake inhibitor). Methods and compositions for treating at least one symptom (e.g., at least one core symptom) of depression in a subject and/or determining or improving the effectiveness of an antidepressant drug taken by a subject are also provided herein.
• US4348396A
  申请人：——

  公开号：US4348396A

  公开（公告）日：1982-09-07
• US8344115B2
  申请人：——

  公开号：US8344115B2

  公开（公告）日：2013-01-01
• US9546401B2
  申请人：——

  公开号：US9546401B2

  公开（公告）日：2017-01-17