4-(5-bromo-3-phenyl-1-benzofuran-2-yl)butan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 4-(5-bromo-3-phenyl-1-benzofuran-2-yl)butan-2-one
• 化学式: C₁₈H₁₅BrO₂
• mdl: MFCD09062581
• 分子量: 343.22
• InChiKey: PZTFAKWBIHHXII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基呋喃 、 4-溴-2-(羟基-苯基-甲基)-苯酚 在 对甲苯磺酸 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以78%的产率得到4-(5-bromo-3-phenyl-1-benzofuran-2-yl)butan-2-one
  参考文献：
  名称：

  [EN] NOVEL BENZOFURAN, BENZOTHIOPHENE, AND INDOLE ANALOGS THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE
  [FR] NOUVEAUX ANALOGUES DE BENZOFURANES, DE BENZOTHIOPHÈNES ET D'INDOLES QUI INHIBENT LA FORMATION D'OLIGOMÈRES TAU ET LEUR PROCÉDÉ D'UTILISATION

  摘要：

  公开号：

  WO2018118782A3

文献信息

• Benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use
  申请人：OLIGOMERIX INC.

  公开号：US11306075B2

  公开（公告）日：2022-04-19

  Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

  本发明公开了新型苯并呋喃类、苯并噻吩类和吲哚类化合物，它们可作为 tau 寡聚体形成的抑制剂，用于治疗神经退行性疾病和相关病症。本发明还涉及所述化合物的药学上可接受的盐、制备所述化合物的工艺、用于制备所述化合物的中间体以及含有所述化合物的药物组合物。本发明进一步涉及所述化合物、所述化合物的盐和所述组合物在治疗神经退行性疾病和相关疾病中的使用方法。
• NOVEL BENZOFURAN, BENZOTHIOPHENE, AND INDOLE ANALOGS THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE
  申请人：OLIGOMERIX INC.

  公开号：US20210130335A1

  公开（公告）日：2021-05-06

  Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.
• [EN] NOVEL BENZOFURAN, BENZOTHIOPHENE, AND INDOLE ANALOGS THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE<br/>[FR] NOUVEAUX ANALOGUES DE BENZOFURANES, DE BENZOTHIOPHÈNES ET D'INDOLES QUI INHIBENT LA FORMATION D'OLIGOMÈRES TAU ET LEUR PROCÉDÉ D'UTILISATION
  申请人：OLIGOMERIX INC

  公开号：WO2018118782A3

  公开（公告）日：2018-08-09