4-(2,3-diphenyl-3,4-dihydroquinazolin-4-yl)-N,N-dimethylaniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(2,3-diphenyl-3,4-dihydroquinazolin-4-yl)-N,N-dimethylaniline
• 英文别名: 4-(2,3-diphenyl-4H-quinazolin-4-yl)-N,N-dimethylaniline
• 化学式: C₂₈H₂₅N₃
• 分子量: 403.527
• InChiKey: NRPXVWRROJXPBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  18.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(2-氨基苄基)苯胺 在 iron(II) chloride 作用下， 以 乙醇 、 1,2-二氯乙烷 为溶剂， 反应 7.0h， 生成 4-(2,3-diphenyl-3,4-dihydroquinazolin-4-yl)-N,N-dimethylaniline
  参考文献：
  名称：

  Iron-catalyzed C–C bond formation via cross dehydrative coupling reaction of N-heterocyclic aminols with electron rich arenes: facile access to C4-aryl-dihydroquinazolines

  摘要：

  The direct coupling of sp(3) C-OH bond of N -heterocyclic aminols with sp(2) C-H bond of electron rich arenes have been achieved via iron catalyzed dehydrative cross coupling strategy. This novel protocol provides an efficient and straight forward route to access biologically important C4-aryl-3,4dihydroquinazoline derivatives through the reaction of C4-hydroxy-3,4-dihydroquinazolineiaminol with phenol and aniline derivatives under mild reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.12.040

文献信息

• Iron-catalyzed C–C bond formation via cross dehydrative coupling reaction of N-heterocyclic aminols with electron rich arenes: facile access to C4-aryl-dihydroquinazolines
  作者：R. Arun Kumar、A. Srinivasulu、G. Saidulu、P. Santhosh Kumar、B. Sridhar、K. Rajender Reddy

  DOI：10.1016/j.tet.2015.12.040

  日期：2016.2

  The direct coupling of sp(3) C-OH bond of N -heterocyclic aminols with sp(2) C-H bond of electron rich arenes have been achieved via iron catalyzed dehydrative cross coupling strategy. This novel protocol provides an efficient and straight forward route to access biologically important C4-aryl-3,4dihydroquinazoline derivatives through the reaction of C4-hydroxy-3,4-dihydroquinazolineiaminol with phenol and aniline derivatives under mild reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.