(2-methoxyethyl)-(6-methylquinazolin-4-yl)amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (2-methoxyethyl)-(6-methylquinazolin-4-yl)amine
• 英文别名: Cambridge id 6143096；N-(2-methoxyethyl)-6-methylquinazolin-4-amine
• 化学式: C₁₂H₁₅N₃O
• mdl: MFCD02081787
• 分子量: 217.271
• InChiKey: KFOOGDOMAVEAHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-5-甲基苯腈 在 溶剂黄146 、 苯磺酰氯 作用下， 以 乙腈 为溶剂， 反应 0.17h， 生成 (2-methoxyethyl)-(6-methylquinazolin-4-yl)amine
  参考文献：
  名称：

  Efficient Synthesis of 4-Aminoquinazoline and Thieno[3,2-d]pyrimidin-4-ylamine Derivatives by Microwave Irradiation

  摘要：

  A simple, efficient, and high-yielding synthesis of quinazolin-4-ylamine and thieno[3,2-d]pyrimidin-4-ylamine derivatives is reported under microwave irradiation conditions. Reaction conditions including temperature, solvent, and reaction time have been studied. An efficient parallel workup procedure was developed to generate a small library (23 compounds) in a short time period.

  DOI：

  10.1021/ol047919y

文献信息

• Identification of CDKI pathway inhibitors
  申请人：Chang Bey-Dih

  公开号：US20080033000A1

  公开（公告）日：2008-02-07

  The invention relates to the inhibition of the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases.
• CDKI Pathway inhibitors and uses thereof to regulate expression to TAU protein
  申请人：Porter Donald

  公开号：US20100190807A1

  公开（公告）日：2010-07-29

  The invention relates to the inhibition of the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to methods for inhibiting increases in MAPT expression induced by the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases.
• Efficient Synthesis of 4-Aminoquinazoline and Thieno[3,2-<i>d</i>]pyrimidin-4-ylamine Derivatives by Microwave Irradiation
  作者：David S. Yoon、Ying Han、Todd M. Stark、James C. Haber、Brian T. Gregg、Sara B. Stankovich

  DOI：10.1021/ol047919y

  日期：2004.12.1

  A simple, efficient, and high-yielding synthesis of quinazolin-4-ylamine and thieno[3,2-d]pyrimidin-4-ylamine derivatives is reported under microwave irradiation conditions. Reaction conditions including temperature, solvent, and reaction time have been studied. An efficient parallel workup procedure was developed to generate a small library (23 compounds) in a short time period.