7-[1-(2-cyanoacetyl)piperidin-4-yl]-2-(4-phenoxyphenyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-[1-(2-cyanoacetyl)piperidin-4-yl]-2-(4-phenoxyphenyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide
• 英文别名: 7-[1-(2-Cyanoacetyl)piperidin-4-yl]-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide；7-[1-(2-cyanoacetyl)piperidin-4-yl]-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
• 化学式: C₂₇H₂₈N₆O₃
• 分子量: 484.558
• InChiKey: JZZVHDLMZFJCQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-[1-(2-cyanoacetyl)piperidin-4-yl]-2-(4-phenoxyphenyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide 、 环丙甲醛 在 哌啶 作用下， 以 甲醇 为溶剂， 反应 15.0h， 以45%的产率得到(S)-7-(1-(2-cyano-3-cyclopropylacryloyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
  参考文献：
  名称：

  TWI602818

  摘要：

  公开号：

文献信息

• FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
  申请人：BeiGene, Ltd.

  公开号：US20170073349A1

  公开（公告）日：2017-03-16

  The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.

  本发明涉及公式（I）的融合杂环化合物及其盐、组合物和使用方法。特别地，本文披露了某些融合杂环化合物，可以用于抑制蛋白激酶，包括布鲁顿酪氨酸激酶（Btk），并用于治疗由其介导的疾病。
• Fused heterocyclic compounds as protein kinase inhibitors
  申请人：Beigene, Ltd.

  公开号：US20150259354A1

  公开（公告）日：2015-09-17

  The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.

  本发明涉及公式（I）的融合杂环化合物及其盐，组合物和使用方法。具体而言，本发明揭示了某些融合杂环化合物，可用于抑制蛋白激酶，包括布鲁顿酪氨酸激酶（Btk），并用于治疗由此介导的疾病。
• Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators
  申请人：BeiGene, Ltd.

  公开号：US10005782B2

  公开（公告）日：2018-06-26

  The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.

  本发明是式(I)的融合杂环化合物及其盐类、组合物和使用方法。特别是，本文公开的某些融合杂环化合物可用于抑制蛋白激酶，包括布鲁顿酪氨酸激酶（Btk），以及治疗由其介导的疾病。
• Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators
  申请人：BeiGene, Ltd.

  公开号：US10570139B2

  公开（公告）日：2020-02-25

  The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.

  本发明是式(I)的融合杂环化合物及其盐类、组合物和使用方法。特别是，本文公开的某些融合杂环化合物可用于抑制蛋白激酶，包括布鲁顿酪氨酸激酶（Btk），以及治疗由其介导的疾病。
• SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS
  申请人：BeiGene, Ltd.

  公开号：US20180251466A1

  公开（公告）日：2018-09-06

  The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.