2,2-diphenyl-1-isopropyl-1,2-dihydroazeto[2,1-b]quinazoline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-diphenyl-1-isopropyl-1,2-dihydroazeto[2,1-b]quinazoline
• 英文别名: 2,2-Diphenyl-1-propan-2-yl-1,8-dihydroazeto[2,1-b]quinazoline
• 化学式: C₂₅H₂₄N₂
• 分子量: 352.479
• InChiKey: LMIKTEBMQGKLDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-azidobenzylamine 在 aluminum oxide 作用下， 以 甲苯 为溶剂， 反应 13.5h， 生成 2,2-diphenyl-1-isopropyl-1,2-dihydroazeto[2,1-b]quinazoline
  参考文献：
  名称：

  Intramolecular [2 + 2] cycloaddition of ketenimines with imines. Synthesis and chemical behaviour of azeto[2,1-b]quinazolines

  摘要：

  Azeto[2,1-b]quinazolines 5 have been prepared by the novel intramolecular [2 + 2] cycloaddition reaction of ketenimines with imines. The applicability and limitations of the synthetic methodology, and explorations on the reactivity of compounds 5 are discussed. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00855-7

文献信息

• Intramolecular [2 + 2] cycloaddition of ketenimines with imines
  作者：Mateo Alajarín、Pedro Molina、Angel Vidal

  DOI：10.1016/s0040-4039(96)02054-0

  日期：1996.12

  Azeto[2,1-b]quinazolines 11 have been easily prepared by the novel intramolecular [2 + 2] cycloaddition reaction of ketenimines with imines. Copyright (C) 1996 Elsevier Science Ltd
• Intramolecular [2 + 2] cycloaddition of ketenimines with imines. Synthesis and chemical behaviour of azeto[2,1-b]quinazolines
  作者：Mateo Alajarín、Pedro Molina、Angel Vidal、Fulgencio Tovar

  DOI：10.1016/s0040-4020(97)00855-7

  日期：1997.9

  Azeto[2,1-b]quinazolines 5 have been prepared by the novel intramolecular [2 + 2] cycloaddition reaction of ketenimines with imines. The applicability and limitations of the synthetic methodology, and explorations on the reactivity of compounds 5 are discussed. (C) 1997 Elsevier Science Ltd.